120779-86-4Relevant academic research and scientific papers
CONVENIENT SYNTHESIS OF 4-TRIFLUOROMETHYLPYRAZOLES BY CYCLIZATION OF TRIFLUOROACETYLATED HYDRAZONES
Kamitori, Yasuhiro,Hojo, Masaru,Masuda, Ryoichi,Ohara, Seiji,Kawasaki, Kazuyoshi,Yoshikawa, Naohiro
, p. 5281 - 5284 (1988)
Several 4-trifluoromethyl-1-alkylpyrazoles were synthesized in good yields by trifluoroacetic anhydride-pyridine induced cyclization reaction of acylhydrazones prepared from aldehyde dialkylhydrazones and trifluoroacetic anhydride.
4- and 5-Trifluoromethylimidazoles. Novel Cyclization of Trifluoroacetylated Aldehyde Dimethylhydrazones
Kamitori, Yasuhiro,Hojo, Masaru,Masuda, Ryoichi,Ohara, Seiji,Kawasaki, Kazuyoshi,et al.
, p. 487 - 495 (2007/10/02)
Thermally induced cyclization reaction of trifluoroacetylated arylaldehyde dimethylhydrazones 1 in refluxing toluene afforded 1-methyl-4-aryl-5-trifluoromethylimidazoles 2 in good yields.In contrast thermal cyclization of 1 in the presence of silica gel gave regioisomeric 1-methyl-4-trifluoromethyl-5-aryl-imidazoles 5 as major products.These reactions could be extended to the synthesis of related several 1,4,5-trisubstituted imidazoles.
