120779-91-1Relevant academic research and scientific papers
Toward Continuous-Flow Synthesis of Biologically Interesting Pyrazole Derivatives
Das, Amrita,Ishitani, Haruro,Kobayashi, Shū
supporting information, p. 5127 - 5132 (2019/11/13)
A two-step continuous-flow synthesis of substituted pyrazole derivatives has been developed via the formation of vinylidene keto esters as key intermediates. Heterogeneous Ni2+-montmorillonite was found to be an efficient catalyst for orthoester condensation of 1,3-dicarbonyls under flow conditions. The intermediate reacted with methylhydrazine to afford pyrazole derivatives, for which suitable selection of a solvent played a key role in achieving high yields and excellent regioselectivities of the desired products. An application of this protocol has been demonstrated by the synthesis of a key intermediate for biologically active pyrazoles such as Bixafen. (Figure presented.).
CONVENIENT SYNTHESIS OF 4-TRIFLUOROMETHYLPYRAZOLES BY CYCLIZATION OF TRIFLUOROACETYLATED HYDRAZONES
Kamitori, Yasuhiro,Hojo, Masaru,Masuda, Ryoichi,Ohara, Seiji,Kawasaki, Kazuyoshi,Yoshikawa, Naohiro
, p. 5281 - 5284 (2007/10/02)
Several 4-trifluoromethyl-1-alkylpyrazoles were synthesized in good yields by trifluoroacetic anhydride-pyridine induced cyclization reaction of acylhydrazones prepared from aldehyde dialkylhydrazones and trifluoroacetic anhydride.
