1207836-10-9

Basic information

• Product Name: 6-bromo-4-methoxypyrazolo[1,5-a]pyridine-3-carbonitrile
• Synonyms: 6-bromo-4-methoxypyrazolo[1,5-a]pyridine-3-carbonitrile
• CAS NO: 1207836-10-9
• Molecular Formula: C9H6BrN3O
• Molecular Weight: 252.06744
• Mol File: 1207836-10-9.mol
• Article Data: 14

Chemical Properties

• Appearance: /
• Density: 1.67±0.1 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: -1.97±0.30(Predicted)
• CAS DataBase Reference: 6-bromo-4-methoxypyrazolo[1,5-a]pyridine-3-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 6-bromo-4-methoxypyrazolo[1,5-a]pyridine-3-carbonitrile(1207836-10-9)
• EPA Substance Registry System: 6-bromo-4-methoxypyrazolo[1,5-a]pyridine-3-carbonitrile(1207836-10-9)

Safety Data

• Hazardous Substances Data: 1207836-10-9(Hazardous Substances Data)

Usage

Uses

6-bromo-4-methoxypyrazolo[1,5-a]pyridine-3-carbonitrile is an organic intermediate for laboratory R&D processes.

Synthesis

The DMF 10L solution of 2,4,6-trimethylbenzenesulfonic acid 3-bromo-5-methoxypyridinamine salt 2000g (4.96mol, 1.0eq), 2-chloropropene cyanide (7.44mol, 1.5eq) was added with potassium carbonate 684g (4.96mol, 1.0eq) and stirred at 20-30°C for 8h. Then the mixtrue was heated with dropwise 1132g (7.44mol, 1.5eq) of diazabicyclo at 50-60°C for 20h. After the reaction is finished and poured into water 30 L at RT. the solution was filtered, washed with water and recrystallized in ethanol to give a pale yellow solid, 6-bromo-4-methoxypyrazolo[1,5-a]pyridine-3-carbonitrile (702g 56%).

Upstream product

• 107-13-1 acrylonitrile 
• 920-37-6 2-Chloroacrylonitrile 
• 50720-12-2 3-bromo-5-methoxypyridine 
• 17508-17-7 O-(2,4-dinitrophenyl)hydroxylamine 
• 1207839-91-5 6-bromo-4-methoxypyrazolo[1,5-a]pyridine-3-carbaldehyde 
• 1207557-36-5 6-bromo-4-methoxypyrazolo[1,5-a]pyridine 

Downstream Products

• 2152628-33-4 6-(2-hydroxy-2-methylpropoxy)-4-(6-(6-((6-methoxypyridin-3-yl)methyl)-3.6-diazabicyclo[3.1.1]heptan-3-yl)pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile 
• 2222756-24-1 6-bromo-4-(6-fluoropyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile 

Relevant articles and documents

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