1207842-90-7

Basic information

• Product Name: 3,4-Dimethoxy-w-nitrostyren
• Synonyms: 3,4-Dimethoxy-w-nitrostyren
• CAS NO: 1207842-90-7
• Molecular Weight: 209.202
• Mol File: 1207842-90-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3,4-Dimethoxy-w-nitrostyren(CAS DataBase Reference)
• NIST Chemistry Reference: 3,4-Dimethoxy-w-nitrostyren(1207842-90-7)
• EPA Substance Registry System: 3,4-Dimethoxy-w-nitrostyren(1207842-90-7)

Safety Data

• Hazardous Substances Data: 1207842-90-7(Hazardous Substances Data)

Upstream product

• 75-52-5 nitromethane 
• 120-14-9 3,4-dimethoxy-benzaldehyde 

Downstream Products

• 120-20-7 2-(3,4-dimethoxyphenyl)-ethylamine 
• 70360-83-7 1,2-dimethoxy-4-(2-nitroethyl)benzene 

Relevant articles and documents

The influence of substitution at aromatic part of 1,2,3,4-tetrahydroisoquinoline on in vitro and in vivo 5-HT1A/5-HT2A receptor activities of its 1-adamantoyloaminoalkyl derivatives

Further structure-activity relationship (SAR) studies with the 1,2,3,4-tetrahydroisoquinoline (THIQ) class of 5-HT1A ligands led to the synthesis of new 1-adamantoyloaminoalkyl derivatives. The impact of substituent variations in the aromatic part of THIQ moiety on 5-HT1A and 5-HT2A receptor affinities, as well as in vivo functional properties of the investigated compounds were discussed. It was found that modification reduced the binding affinity for 5-HT1A receptors (in comparison with unsubstituted THIQ derivatives); however, the majority of new compounds still remained potent 5-HT1A ligands (Ki = 4.9-46 nM) and most of them showed features of partial agonists of postsynaptic 5-HT1A receptors. At the same time, their 5-HT2A receptor affinity was slightly increased (Ki = 40-1475 nM), which resulted in a loss of 5-HT2A/5-HT1A selectivity. 5-Br,8-OCH3 derivative - the most potent, mixed 5-HT1A/5-HT2A ligand - produced activation of presynaptic 5-HT1A receptors and showed properties of a 5-HT2A receptor antagonist. Copyright