70360-83-7

Basic information

• Product Name: Benzene, 1,2-dimethoxy-4-(2-nitroethyl)-
• CAS NO: 70360-83-7
• Molecular Formula: C10H13NO4
• Molecular Weight: 211.218
• Mol File: 70360-83-7.mol
• Article Data: 19

Chemical Properties

• CAS DataBase Reference: Benzene, 1,2-dimethoxy-4-(2-nitroethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1,2-dimethoxy-4-(2-nitroethyl)-(70360-83-7)
• EPA Substance Registry System: Benzene, 1,2-dimethoxy-4-(2-nitroethyl)-(70360-83-7)

Safety Data

• Hazardous Substances Data: 70360-83-7(Hazardous Substances Data)

Upstream product

• 1207842-90-7 3,4-Dimethoxy-w-nitrostyren 
• 4230-93-7 3,4-dimethoxynitrostyrene 
• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 39220-86-5 2-nitro-1-(3,4-dimethoxyphenyl)ethanol 
• 4230-93-7 1,2-dimethoxy-4-(2-nitro-vinyl)-benzene 

Downstream Products

• 838850-85-4 ethyl 2-diethoxyphosphoryl-5-(3,4-dimethoxyphenyl)-4-nitropentanoate 
• 32372-76-2 N-(3,4-Dimethoxyphenethyl)-3-hydroxybenzylamin 
• 635-85-8 homoveratrylamine hydrochloride 
• 120-20-7 2-(3,4-dimethoxyphenyl)-ethylamine 
• 1027831-57-7 1-[3-(3,4-Dimethoxy-phenyl)-2-nitro-propyl]-2,3,4-trimethoxy-benzene 
• 156775-29-0 C₁₉H₂₃NO₆ 
• 6704-25-2 1,3-di<1-(3,4-dimethoxyphenyl)>acetone 
• 838850-96-7 ethyl 2-diethoxyphosphoryl-5-(3,4-dimethoxyphenyl)-4-oxopentanoate 
• 838851-20-0 3-diethoxyphosphoryl-5-(3,4-dimethoxyphenylmethyl)pyrrolidin-2-one 
• 838851-05-1 3-diethoxyphosphoryl-5-(3,4-dimethoxyphenylmethyl)-3,4-dihydro-2(5H)-furanone 

Relevant articles and documents

Structure–activity relationship and biological evaluation of berberine derivatives as PCSK9 down-regulating agents

Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a secreted protein and its deficiency markedly enhanced the survival rate of patient with cardiovascular diseases (CVDs). Forty berberine (BBR) derivatives were synthesized and evaluated for their activities on down-regulating the transcription of PCSK9 in HepG2 cells, taking BBR as the lead. Structure–activity relationship (SAR) analysis revealed that 2,3-dimethoxy moiety might be beneficial for activity. Among them, 9k displayed the most potent activity with IC50 value of 9.5 ± 0.5 μM, better than that of BBR. Also, it significantly decreased PCSK9 protein level at cellular level, as well as in the liver and serum of mice in vivo. Furthermore, 9k markedly increased LDLR expression and LDL-C clearance via down-regulating PCSK9 protein. The mechanism of action of 9k is targeting HNF1α and/or Sp1 cluster modulation upstream of PCSK9, a different one from BBR. Therefore, 9k might have the potential to be a novel PCSK9 transcriptional inhibitor for the treatment of atherosclerosis, worthy for further investigation.

Enhanced copper-mediated 18F-fluorination of aryl boronic esters provides eight radiotracers for PET applications

[18F]FMTEB, [18F]FPEB, [18F]flumazenil, [18F]DAA1106, [18F]MFBG, [18F]FDOPA, [18F]FMT and [18F]FDA are prepared from the corresponding arylboronic esters and [18

The highly chemoselective transfer hydrogenation of the carbon-carbon double bond of conjugated nitroalkenes by a rhodium complex

Chemoselective transfer hydrogenation of conjugated nitroalkenes catalyzed by [RhCl2Cp·]2-diamine complex (Cp ·=η5-C5Me5) using HCOOH/Et3N (5:2) (TEAF) as a hydrogen source was realized. A variety of nitrostyrenes, β-methyl nitrostyrenes, and 3-methyl-4-nitro-5-alkenyl- isoxazoles were reduced smoothly in good to excellent yields in short reaction time. Other functional groups are inert under the reaction conditions.