1207853-61-9

Basic information

• Product Name: (3R,4R)-3-AMino-1-Boc-4-Methylpiperidine
• Synonyms: (3R,4R)-3-AMino-1-Boc-4-Methylpiperidine;tert-butyl (3R,4R)-3-amino-4-methylpiperidine-1-carboxylate
• CAS NO: 1207853-61-9
• Molecular Formula: C11H22N2O2
• Molecular Weight: 214.30458
• Mol File: 1207853-61-9.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 287.8±33.0 °C(Predicted)
• Appearance: /
• Density: 1.009±0.06 g/cm3(Predicted)
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• PKA: 10.37±0.40(Predicted)
• CAS DataBase Reference: (3R,4R)-3-AMino-1-Boc-4-Methylpiperidine(CAS DataBase Reference)
• NIST Chemistry Reference: (3R,4R)-3-AMino-1-Boc-4-Methylpiperidine(1207853-61-9)
• EPA Substance Registry System: (3R,4R)-3-AMino-1-Boc-4-Methylpiperidine(1207853-61-9)

Safety Data

• Hazardous Substances Data: 1207853-61-9(Hazardous Substances Data)

Usage

General Description

(3R,4R)-3-Amino-1-Boc-4-Methylpiperidine is a chemical compound with the molecular formula C12H24N2O2. It is a derivative of piperidine, a heterocyclic organic compound, and contains an amino group and a Boc (tert-butoxycarbonyl) protecting group. The (3R,4R) stereochemistry indicates the specific conformation of the compound. It is often used as an intermediate in the synthesis of pharmaceuticals and other organic compounds due to its versatile reactivity and potential for various functional group transformations. Additionally, its specific structure and properties make it valuable for research and development in the fields of medicinal chemistry and organic synthesis.

Upstream product

• 3222-50-2 4-methylnicotinic acid 
• 374794-77-1 tert-butyl 4-methyl-3-oxopiperidine-1-carboxylate 
• 32018-96-5 1-benzyl-4-methyl-piperidin-3-one 
• 175406-94-7 1-benzyl-3-oxopiperidine-4-carboxylic acid methyl ester 
• 24424-99-5 di-tert-butyl dicarbonate 
• 1271810-25-3 trans 1-(tert-butoxycarbonyl)-4-methylpiperidine-3-carboxylic acid 
• 1201192-62-2 1-(tert-butyl) 3-methyl 4-methylpiperidine-1,3-dicarboxylate 
• 908244-98-4 methyl 4-methylpiperidine-3-carboxylate 
• 33402-75-4 4-methylnicotinic acid methyl ester 

Downstream Products

• 1312762-44-9 (3R,4R)-3-methylamino-4-methylpiperidine-1-carboxylic acid tert-butyl ester 

Relevant articles and documents

HETEROCYCLIC COMPOUNDS FOR THE TREATMENT OF ABNORMAL CELLULAR PROLIFERATION

This invention is in the area of heterocyclic-based compounds for the treatment of disorders involving abnormal cellular proliferation, including but not limited to tumors and cancers.

The protection of the nitrogen of (3R, 4R) -3 - methylamino -4 - methyl piperidine asymmetric synthesis method, relevant intermediate and a method for preparing raw materials thereof

The invention relates to a preparation method of nitrogen protected (3R,4R)-3-methylamino-4-methylpiperidine (I). The method comprises the following steps: carrying out a reductive amination reaction on a compound of formula (III) and (R)-1-phenylethylamine to obtain a compound of formula (II), removing chiral prosthetic groups from the compound of formula (II), and adding a methyl group to the amino group of the compound of formula (II) in order to obtain nitrogen protected (3R,4R)-3-methylamino-4-methylpiperidine (I), wherein R in each of the formula (I), the formula (II) and the formula (III) is an amino protection group or hydrogen, and the amino protection group can be C1-4 alkoxycarbonyl, benzyloxycarbonyl or benzyl groups which can be removed through hydrolysis or hydrogenation. The asymmetric synthesis method of nitrogen protected (3R,4R)-3-methylamino-4-methylpiperidine (I) has the advantages of reasonable technology, concise route, obtaining of the required product in a high ee value manner by constructing two chiral centers through chiral induced one-step reductive amination, cheap raw materials, and no waste isomer emission, and is suitable for large-scale industrialized production.

BRUTON'S TYROSINE KINASE INHIBITORS

The present invention provides compounds useful as inhibitors of Btk, compositions thereof, and methods of using the same.