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1207862-94-9

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1207862-94-9 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1207862-94-9 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,0,7,8,6 and 2 respectively; the second part has 2 digits, 9 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 1207862-94:
(9*1)+(8*2)+(7*0)+(6*7)+(5*8)+(4*6)+(3*2)+(2*9)+(1*4)=159
159 % 10 = 9
So 1207862-94-9 is a valid CAS Registry Number.

1207862-94-9Upstream product

1207862-94-9Downstream Products

1207862-94-9Relevant articles and documents

Design, synthesis and biological evaluation of 6-(benzyloxy)-4-methylquinolin-2(1H)-one derivatives as PDE3 inhibitors

Nikpour, Mohsen,Sadeghian, Hamid,Saberi, Mohammad Reza,Nick, Reza Shafiee,Seyedi, Seyed Mohammad,Hosseini, Azar,Parsaee, Heydar,Bozorg, Alireza Taghian Dasht

, p. 855 - 862 (2010)

Selective PDE3 (phosphodiesterase 3) inhibitors improve cardiac contractility and may be used in congestive heart failure. However, their proarrhythmic potential is the most important side effect. In this work ten new synthetic compounds (3-[(4-methyl-2-oxo-1,2-dihydro-6-quinolinyl)oxy]methylbenzamide analogs: 4a-j) were designed, synthesized and tested for the inhibitory activity against human PDE3A and PDE3B. The strategy of the design was based on the structure of vesnarinone (a selective PDE3 inhibitor) and its docking analysis results. The synthetic compounds showed better PDE3 inhibitory activity in comparison with vesnarinone. Using docking analysis, a common binding model of each compound toward PDE3 was suggested. In the next step the potential cardiotonic activity of the best PDE3A inhibitors (4b, IC50 = 0.43 ± 0.04 μM) was evaluated by using the spontaneously beating atria model. In the experiment, atrium of reserpine-treated rat was isolated and the contractile and chronotropic effects of the synthetic compound were assessed. That was carried out in comparison with vesnarinone. The best pharmacological profile was obtained for the compound 4b, which displayed selectivity for increasing the force of contraction (46 ± 3% change over the control) rather than the frequency rate (16 ± 4% change over the control) at 100 μM.

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