120791-65-3

Basic information

• Product Name: N-Methyl-N-(1-benzyl-1,3-dihydro-2-oxo-3,3-dimethyl-2H-5-indolyl)formamide
• Synonyms: N-Methyl-N-(1-benzyl-1,3-dihydro-2-oxo-3,3-dimethyl-2H-5-indolyl)formamide
• CAS NO: 120791-65-3
• Molecular Weight: 308.38
• Mol File: 120791-65-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-Methyl-N-(1-benzyl-1,3-dihydro-2-oxo-3,3-dimethyl-2H-5-indolyl)formamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-Methyl-N-(1-benzyl-1,3-dihydro-2-oxo-3,3-dimethyl-2H-5-indolyl)formamide(120791-65-3)
• EPA Substance Registry System: N-Methyl-N-(1-benzyl-1,3-dihydro-2-oxo-3,3-dimethyl-2H-5-indolyl)formamide(120791-65-3)

Safety Data

• Hazardous Substances Data: 120791-65-3(Hazardous Substances Data)

Upstream product

• 120791-64-2 1-Benzyl-1,3-dihydro-3,3-dimethyl-5-nitro-2H-indol-2-one 
• 925220-72-0 5-Amino-1-benzyl-3,3-dimethyl-1,3-dihydro-indol-2-one 
• 100-44-7 benzyl chloride 
• 100511-00-0 1,3-Dihydro-3,3-dimethyl-5-nitro-2H-indol-2-one 
• 74-88-4 methyl iodide 

Relevant articles and documents

Nonsteroidal Cardiotonics. 2. The Inotropic Activity of Linear, Tricyclic 5-6-5 Fused Heterocycles

We previously reported the structure-activity relationships (SAR) of adibendan (1), a potent and long-acting cardiotonic.This paper describes the synthesis of a novel series of linear, tricyclic fused heterocycles of the 5-6-5 type.The compounds were evaluated for positive inotropic activity in anesthetized rats, cats, and dogs.Changes in left ventricular dP/dt were measured as an index of cardiac contractility.The increase in contractility was not mediated via stimulation of β-adrenergic receptors.The data revealed the intrinsic positive inotropic activity of the parent compound of this series, 5,7-dihydro-7,7-dimethylpyrrolobenzimidazol-6(1H)-one (2).The structural features that impart optimal inotropic activity are presented and compared with those of the 4,5-dihydro-3(2H)-pyridazinone series.The most potent compounds were evaluated orally in conscious dogs with implanted Konigsberg pressure transducers to measure ventricular pressures, and their effect on left ventricular dP/dt was compared with that of 1, pimobendan, and indolidan.After administration of 1 mg/kg, 1, 3, 7, 19, 22, 24, 31, 54, pimobendan, and indolidan were equipotent, but only with 1, 31, pimobendan, and indolidan, durations of action exceeded 6 h.