1207965-95-4Relevant articles and documents
Scalable and straightforward synthesis of a 2-alkyl-7-arylbenzo-thiophene as a GPR52 agonist via a hemithioindigo derivative
Fukuda, Naohiro,Ikemoto, Tomomi
, p. 3467 - 3472 (2015/11/17)
A simple and efficient procedure has been developed for the synthesis of the GPR52 agonist N-(2-amino-2-oxoethyl)-3-{4-fluoro-2-[3-(trifluoromethyl)benzyl]-1-benzothien-7-yl}benzamide. The benzo thiophene unit was directly constructed by reduction of a hemithioindigo derivative prepared by an intramolecular Friedel-Crafts cyclization of (phenylsulfanyl)acetic acid, followed by dehydrative benzylidene formation.
AMIDE COMPOUND
-
Page/Page column 119, (2010/03/04)
A compound having GPR52 agonist activity or a salt thereof is provided. The compound can be provided as a preventive/therapeutic agent for schizophrenia or the like. The compound is represented by the following formula: wherein A represents —CONRa— or —NRaCO—, Ra represents a hydrogen atom or the like,B represents a hydrogen atom or the like,a ring Cy1 represents a six-membered aromatic ring which may have one or more substituents in addition to a group represented by -A-B,a ring Cy2 represents a six-membered ring which may be substituted with a halogen atom or the like,a ring Cy3 represents a five- or six-membered ring which may have one or more substituents;X represents C1-2 alkylene or the like,m represents an integer of 0 to 2, anda ring Cy4 represents a six-membered aromatic ring which may have one or more substituents.