1207969-15-0

Basic information

• Product Name: 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-[3-(trifluoromethyl)benzyl]-1-benzofuran
• Synonyms: 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-[3-(trifluoromethyl)benzyl]-1-benzofuran
• CAS NO: 1207969-15-0
• Molecular Weight: 402.221
• Mol File: 1207969-15-0.mol

Chemical Properties

• CAS DataBase Reference: 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-[3-(trifluoromethyl)benzyl]-1-benzofuran(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-[3-(trifluoromethyl)benzyl]-1-benzofuran(1207969-15-0)
• EPA Substance Registry System: 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-[3-(trifluoromethyl)benzyl]-1-benzofuran(1207969-15-0)

Safety Data

• Hazardous Substances Data: 1207969-15-0(Hazardous Substances Data)

Upstream product

• 1207969-02-5 (4-bromo-1-benzofuran-2-yl)[3-(trifluoromethyl)phenyl]methanone 
• 22532-61-2 2-bromo-6-hydroxybenzaldehyde 
• 2003-10-3 2-bromo-1-[3-(trifluoromethyl)phenyl]ethanone 
• 1207969-03-6 4-bromo-2-[3-(trifluoromethyl)benzyl]-1-benzofuran 
• 73183-34-3 bis(pinacol)diborane 

Downstream Products

• 1313197-56-6 3,5-dimethyl-N-[2-(1-methylethoxy)ethyl]-1-[2-[3-(trifluoromethyl)benzyl]-1-benzofuran-4-yl]-1H-pyrazole-4-carboxamide 
• 1313197-55-5 3,5-dimethyl-1-[2-[3-(trifluoromethyl)benzyl]-1-benzofuran-4-yl]-1H-pyrazole-4-carboxamide 
• 1313197-54-4 N-(2-hydroxyethyl)-3,5-dimethyl-1-[2-[3-(trifluoromethyl)benzyl]-1-benzofuran-4-yl]-1H-pyrazole-4-carboxamide 
• 1313197-53-3 N-(2-amino-2-oxoethyl)-3,5-dimethyl-1-[2-[3-(trifluoromethyl)benzyl]-1-benzofuran-4-yl]-1H-pyrazole-4-carboxamide 
• 1313196-53-0 3,5-dimethyl-1-[2-[3-(trifluoromethyl-)benzyl]-1-benzofuran-4-yl]-1H-pyrazole-4-carboxylic acid 
• 1313196-52-9 ethyl 3,5-dimethyl-1-[2-[3-(trifluoromethyl)benzyl]-1-benzofuran-4-yl]-1H-pyrazole-4-carboxylate 
• 1313196-27-8 ethyl 4-methyl-2-[2-[3-(trifluoromethyl)benzyl]-1-benzofuran 4-yl]-1,3-thiazole-5-carboxylate 

Relevant articles and documents

AMIDE COMPOUND

A compound represented by the formula (I) wherein ring Cy1 is a 5-membered aromatic heterocycle optionally further substituted besides a group represented by -A-B, ring Cy2 is an optionally substituted benzene ring, ring Cy3 is an optionally substituted 5-membered aromatic heterocycle, ring Cy4 is an optionally substituted 6-membered aromatic ring, A is -CONRa- or -NRaCO-, Ra is a hydrogen atom or a substituent, B is a hydrogen atom or an optionally substituted C1-6 alkyl-group, X is an optionally substituted C1-2 alkylene, -Y-, -Y-CH2- or - CH2-Y-, Y is an oxygen atom, -NRb- or -S(O)m-, Rb is a hydrogen atom or a substituent, and m is 0, 1 or 2, provided that N-methyl-4-[2-[3,4,5-trimethoxyphenyl)amino]-1,3-benzoxazol-7-yl]thiophene-2-carboxamide is excluded, or a salt thereof, has an agonistic action on GPR52, and is useful as an agent for the prophylaxis or treatment of schizophrenia and the like.

AMIDE COMPOUND

A compound having GPR52 agonist activity or a salt thereof is provided. The compound can be provided as a preventive/therapeutic agent for schizophrenia or the like. The compound is represented by the following formula: wherein A represents —CONRa— or —NRaCO—, Ra represents a hydrogen atom or the like,B represents a hydrogen atom or the like,a ring Cy1 represents a six-membered aromatic ring which may have one or more substituents in addition to a group represented by -A-B,a ring Cy2 represents a six-membered ring which may be substituted with a halogen atom or the like,a ring Cy3 represents a five- or six-membered ring which may have one or more substituents;X represents C1-2 alkylene or the like,m represents an integer of 0 to 2, anda ring Cy4 represents a six-membered aromatic ring which may have one or more substituents.