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1207976-45-1

(3β,18β,20β)-3-(methoxyamino)-11-oxoolean-12-en-29-oic acid diphenylmethyl ester is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • (3β,18β,20β)-3-(methoxyamino)-11-oxoolean-12-en-29-oic acid diphenylmethyl ester

    Cas No: 1207976-45-1

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  • 1207976-45-1 Structure

  • Basic information

    1. Product Name: (3β,18β,20β)-3-(methoxyamino)-11-oxoolean-12-en-29-oic acid diphenylmethyl ester
    2. Synonyms: (3β,18β,20β)-3-(methoxyamino)-11-oxoolean-12-en-29-oic acid diphenylmethyl ester
    3. CAS NO:1207976-45-1
    4. Molecular Formula:
    5. Molecular Weight: 665.957
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1207976-45-1.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: (3β,18β,20β)-3-(methoxyamino)-11-oxoolean-12-en-29-oic acid diphenylmethyl ester(CAS DataBase Reference)
    10. NIST Chemistry Reference: (3β,18β,20β)-3-(methoxyamino)-11-oxoolean-12-en-29-oic acid diphenylmethyl ester(1207976-45-1)
    11. EPA Substance Registry System: (3β,18β,20β)-3-(methoxyamino)-11-oxoolean-12-en-29-oic acid diphenylmethyl ester(1207976-45-1)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1207976-45-1(Hazardous Substances Data)

1207976-45-1 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1207976-45-1 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,0,7,9,7 and 6 respectively; the second part has 2 digits, 4 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1207976-45:
(9*1)+(8*2)+(7*0)+(6*7)+(5*9)+(4*7)+(3*6)+(2*4)+(1*5)=171
171 % 10 = 1
So 1207976-45-1 is a valid CAS Registry Number.

1207976-45-1Relevant articles and documents

Synthesis of novel 3-amino and 29-hydroxamic acid derivatives of glycyrrhetinic acid as selective 11β-hydroxysteroid dehydrogenase 2 inhibitors

Stanetty, Christian,Czollner, Laszlo,Koller, Iris,Shah, Priti,Gaware, Rawindra,Cunha, Thierry Da,Odermatt, Alex,Jordis, Ulrich,Kosma, Paul,Cla?en-Houben, Dirk

experimental part, p. 7522 - 7541 (2011/01/04)

Glycyrrhetinic acid, the metabolite of the natural product glycyrrhizin, is a well known nonselective inhibitor of 11β-hydroxysteroid dehydrogenase (11β-HSD) type 1 and type 2. Whereas inhibition of 11β-HSD1 is currently under consideration for treatment of metabolic diseases, such as obesity and diabetes, 11β-HSD2 inhibitors may find therapeutic applications in chronic inflammatory diseases and certain forms of cancer. So far, no selective 11β-HSD2 inhibitor has been developed and neither animal studies nor clinical trials have been reported based on 11β-HSD2 inhibition. Starting from the lead compound glycyrrhetinic acid, novel triterpene type derivatives were synthesized and analyzed for their biological activity against overexpressed human 11β-HSD1 and 11β-HSD2 in cell lysates. Several hydroxamic acid derivatives showed high selectivity for 11β-HSD2. The most potent and selective compound is active against human 11β-HSD2 in the low nanomolar range with a 350-fold selectivity over human 11β-HSD1.

Synthesis of glycyrrhetinic acid derivatives for the treatment of metabolic diseases

Beseda, Igor,Czollner, Laszlo,Shah, Priti S.,Khunt, Rupesh,Gaware, Rawindra,Kosma, Paul,Stanetty, Christian,Ruiz-Ruiz, Maria Carmen del,Amer, Hassan,Mereiter, Kurt,Cunha, Thierry Da,Odermatt, Alex,Classen-Houben, Dirk,Jordis, Ulrich

experimental part, p. 433 - 454 (2010/03/30)

The effect of glycyrrhetinic acid (GA) and GA-derivatives towards 11β-hydroxysteroid dehydrogenase (11β-HSD) was investigated. Novel compounds with modifications at positions C-3, C-11 and C-29 of the GA skeleton were prepared. Single crystal X-ray diffraction data of selected substances are reported and discussed.

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