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Usage

Uses

Used in Pharmaceutical Industry:
(S)-4-Benzyl-3-methylmorpholine is used as a building block for the synthesis of various drugs and organic compounds due to its unique structure and properties, which make it valuable for drug discovery and development.
Used in Chemical Research:
(S)-4-Benzyl-3-methylmorpholine is utilized in chemical research for studying its potential therapeutic effects and understanding its interactions with other molecules, which can contribute to the advancement of pharmaceutical science.
Used as a Reagent in Organic Synthesis:
In the field of organic synthesis, (S)-4-Benzyl-3-methylmorpholine is employed as a reagent, facilitating the creation of new compounds and contributing to the development of novel chemical processes.
Considering its chiral nature, the stereochemistry of (S)-4-Benzyl-3-methylmorpholine is crucial in its applications and synthesis processes, ensuring that the correct enantiomer is used for desired effects and minimizing potential side effects.

Upstream product

• 100-52-7 benzaldehyde 
• 65943-49-9 (S)-2-{[1-Phenyl-meth-(E)-ylidene]-amino}-propan-1-ol 
• 6940-80-3 (S)-N-benzylalaninol 
• 119128-21-1 (5S)-5-methyl-4-(phenylmethyl)-3-morpholinone 
• 127536-05-4 (2-Allyloxy-ethyl)-benzyl-amine 
• 51070-67-8 2-bromo-1-(2-chloro-ethoxy)-propane 
• 100-46-9 benzylamine 

Downstream Products

• 350595-57-2 (S)-3-methylmorpholine 

Relevant academic research and scientific papers

A N-heterocyclic carbene (NHC) platinum complex as pre-catalyst for the intramolecular hydroamination of olefins with secondary alkylamines and oxidative amination of ω-alkenic amines

A N-heterocyclic carbene (NHC) platinum complex 3 prepared from BINAM was found to be a highly effective pre-catalyst for the intramolecular hydroamination of olefins with secondary alkylamines to give the corresponding intramolecular hydroamination products in excellent yields. The substrate scope has been carefully examined and the plausible reaction mechanism has been also proposed.

Structure-based design of potent and selective 3-phosphoinositide-dependent kinase-1 (PDK1) inhibitors

Phosphoinositide-dependent protein kinase-1(PDK1) is a master regulator of the AGC family of kinases and an integral component of the PI3K/AKT/mTOR pathway. As this pathway is among the most commonly deregulated across all cancers, a selective inhibitor of PDK1 might have utility as an anticancer agent. Herein we describe our lead optimization of compound 1 toward highly potent and selective PDK1 inhibitors via a structure-based design strategy. The most potent and selective inhibitors demonstrated submicromolar activity as measured by inhibition of phosphorylation of PDK1 substrates as well as antiproliferative activity against a subset of AML cell lines. In addition, reduction of phosphorylation of PDK1 substrates was demonstrated in vivo in mice bearing OCl-AML2 xenografts. These observations demonstrate the utility of these molecules as tools to further delineate the biology of PDK1 and the potential pharmacological uses of a PDK1 inhibitor.

Arylsulfonic acid salts of pyrimidine-based antiviral

Salts of pyrimidine derivatives are provided having the formula: wherein R represents hydrogen, methyl or ethyl; Z represents a substituted or unsubstituted 1-piperidinyl, a substituted or unsubstituted 4-morpholinyl, or a substituted or unsubstituted 1-pyrrolidinyl; and Ar represents a substituted or unsubstituted phenyl or a substituted or unsubstituted naphthyl. These salts are particularly useful as antiviral agents (e.g., to treat CMV infections).

Synthesis and Reaction of Optically Active Morpholinones

The reactions of variously substituted chiral morpholin-2-and-3-ones chemoselectively synthesized from chiral amino acids and lactic acid as the chiral source are described.