120800-93-3Relevant academic research and scientific papers
Nucleophilic Ring-Opening Reactions of Morpholin-2-ones. A Resolution of dl-(Secondary-alkyl)amines
Kashima, Choji,Harada, Kazuo
, p. 789 - 792 (2007/10/02)
The alcoholysis of morpholin-2-ones yielded an equilibrium mixture of morpholin-2-one and the corresponding hydroxy ester.The equilibrium constants for the methanolysis of several sustituted morpholin-2-ones were determined.Treatment of optically active morpholin-2-ones with (secondary-alkyl)amines resulted in stereoselective ring opening to afford hydroxy amides with up to 30percent de.Hydrolysis of one such hydroxy amide regenerated the optically active (secondary-alkyl)amine and the morpholin-2-one.
Synthesis and Reaction of Optically Active Morpholinones
Kashima, Choji,Harada, Kazuo
, p. 1521 - 1526 (2007/10/02)
The reactions of variously substituted chiral morpholin-2-and-3-ones chemoselectively synthesized from chiral amino acids and lactic acid as the chiral source are described.
