1208006-24-9Relevant academic research and scientific papers
ANTIFUNGAL COMPOUNDS CONTAINING BENZOTHIAZINONE, BENZOXAZINONE OR BENZOXAZOLINONE AND PROCESS THEREOF
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Page/Page column 10, (2010/05/13)
The present invention discloses novel compounds of the Formula (1), comprising benzothiazinone, benzoxazinone or benzoxazolinone moieties having antifungal activity, method for preparing these compounds and the use of these compounds as antifungal agents
Fluconazole analogues containing 2H-1,4-benzothiazin-3(4H)-one or 2H-1,4-benzoxazin-3(4H)-one moieties, a novel class of anti-Candida agents
Borate, Hanumant B.,Maujan, Suleman R.,Sawargave, Sangmeshwer P.,Chandavarkar, Mohan A.,Vaiude, Sharangi R.,Joshi, Vinay A.,Wakharkar, Radhika D.,Iyer, Ramki,Kelkar, Ramesh G.,Chavan, Subhash P.,Kunte, Sunita S.
supporting information; experimental part, p. 722 - 725 (2010/06/12)
As a part of our program to develop new antifungal agents, a series of fluconazole analogues was designed and synthesized wherein one of the triazole moieties in fluconazole was replaced with 2H-1,4-benzothiazin-3(4H)-one or 2H-1,4-benzoxazin-3(4H)-one moiety. The new chemical entities thus synthesized were screened against various fungi and it was observed that the compounds 4a and 4i are potent inhibitors of Candida strains. The structure-activity relationship for these compounds is discussed.
