120801-24-3Relevant academic research and scientific papers
Enantioselective dearomative [3+2] annulation of 5-amino-isoxazoles with quinone monoimines
Liu, Hui,Yan, Yingkun,Zhang, Jiayan,Liu, Min,Cheng, Shaobing,Wang, Zhouyu,Zhang, Xiaomei
supporting information, p. 13591 - 13594 (2020/11/17)
The first enantioselective dearomative [3+2] annulation of 5-amino-isoxazoles with quinone monoimines was realized using a chiral phosphoric acid as catalyst. Various novel (bridged) isoxazoline fused dihydrobenzofurans bearing two continuous quaternary stereocenters were achieved in moderate to good yields (up to 94%) with moderate to good enantioselectivities (up to 98% ee). The absolute configurations of two products were assigned by X-ray crystal structural analyses and a plausible reaction mechanism was proposed. This journal is
Insight into 2-phenylpyrazolo[1,5-a]pyrimidin-3-yl acetamides as peripheral benzodiazepine receptor ligands: Synthesis, biological evaluation and 3D-QSAR investigation
Selleri, Silvia,Gratteri, Paola,Costagli, Camilla,Bonaccini, Claudia,Costanzo, Annarella,Melani, Fabrizio,Guerrini, Gabriella,Ciciani, Giovanna,Costa, Barbara,Spinetti, Francesca,Martini, Claudia,Bruni, Fabrizio
, p. 4821 - 4834 (2007/10/03)
The present paper reports the synthesis and binding studies of new 2-phenylpyrazolo[1,5-a]pyrimidin-3-yl acetamides as selective Peripheral Benzodiazepine Receptor (PBR) ligands. The variability of substituents at the 3-position was investigated and a 3D-
Hunig's Base-Magnesium Chloride Mediated Carbon Alkylation and Oxygen Acylation of Benzoylacetonitrile
Mansour, Tarek S.
, p. 3437 - 3440 (2007/10/02)
In the presence of Hunig's base and anhydrous magnesium chloride, benzoylacetonitrile (1) reacts with 2-haloketones and -esters to give C-alkylated products which may cyclize to polysubstituted furans whereas with acid chlorides O-acylated products are obtained as separable mixtures of E and Z isomers.
