1208066-49-2Relevant academic research and scientific papers
Highly diastereoselective zinc-catalyzed propargylation of tert-butanesulfinyl lmines
Fandrick, Daniel R.,Johnson, Courtney S.,Fandrick, Keith R.,Reeves, Jonathan T.,Tan, Zhulin,Lee, Heewon,Song, Jinhua J.,Yee, Nathan K.,Senanayake, Chris H.
supporting information; experimental part, p. 748 - 751 (2010/04/05)
(Chemical Equetion Presentation) A zinc-catalyzed diastereoselective propargylation of t-butanesulfinyl imines is presented. The methodology provided both aliphatic and aryl homopropargylic amines in up to 98:2 and 99.8:0.2 dr, respectively. The utility of the homopropargylic amines was demonstrated by the application to the synthesis of a cis-substituted pyrido-indole through a diastereoselective Pictet-Spengler cyclization.
