1208072-80-3Relevant articles and documents
Discovery of novel 2-[2-(3-hydroxy-pyridin-2-yl)-thiazol-4-yl]-acetamide derivatives as HIF prolyl 4-hydroxylase inhibitors; SAR, synthesis and modeling evaluation
Hong, Yong Rae,Kim, Hyun Tae,Ro, Seonggu,Cho, Joong Myung,Lee, Sang Hwi,Kim, In Su,Jung, Young Hoon
supporting information, p. 3142 - 3145 (2014/06/24)
The design, synthesis, and capacity to inhibit HIF prolyl 4-hydroxylases (PHDs) are described for 2-[2-(3-hydroxy-pyridin-2-yl)-thiazol-4-yl]-acetamide analogs. These analogs revealed two kinds of novel scaffolds as PHD2 inhibitors. Synthetic routes were