36057-46-2

Basic information

• Product Name: 5-Bromo-3-Methoxy-Pyridine2-Carbonitrile
• Synonyms: 5-Bromo-3-Methoxy-Pyridine2-Carbonitrile;5-Bromo-3-methoxypicolinonitrile
• CAS NO: 36057-46-2
• Molecular Formula: C₇H₅BrN₂O
• Molecular Weight: 213.0314
• Mol File: 36057-46-2.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 310.9 °C at 760 mmHg
• Flash Point: 141.9 °C
• Appearance: /
• Density: 1.65 g/cm³
• Vapor Pressure: 0.000581mmHg at 25°C
• Refractive Index: 1.587
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -7.15±0.10(Predicted)
• CAS DataBase Reference: 5-Bromo-3-Methoxy-Pyridine2-Carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Bromo-3-Methoxy-Pyridine2-Carbonitrile(36057-46-2)
• EPA Substance Registry System: 5-Bromo-3-Methoxy-Pyridine2-Carbonitrile(36057-46-2)

Safety Data

• Hazard Codes: T
• Statements: 25
• Safety Statements: 45
• RIDADR: UN 2811 6.1 / PGIII
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 36057-46-2(Hazardous Substances Data)

Usage

General Description

5-bromo-3-methoxy-pyridine-2-carbonitrile is a chemical compound with the molecular formula C7H5BrN2O. It is a pyridine derivative with a bromine atom at the 5-position and a methoxy group at the 3-position. The carbonitrile group, consisting of a cyano group attached to a carbon atom, is located at the 2-position of the pyridine ring. 5-Bromo-3-Methoxy-Pyridine2-Carbonitrile is used as a building block in organic synthesis, particularly in the pharmaceutical and agrochemical industries, where it serves as a precursor for the synthesis of various biologically active molecules. Its unique structure and reactivity make it a valuable intermediate for the synthesis of complex molecules with potential applications in medicinal chemistry and crop protection.

InChI:InChI=1/C7H5BrN2O/c1-11-7-2-5(8)4-10-6(7)3-9/h2,4H,1H3

Upstream product

• 573675-25-9 5-bromo-3-nitropyridine-2-carbonitrile 
• 124-41-4 sodium methylate 
• 67-56-1 methanol 
• 886373-28-0 5-bromo-3-fluoropyridine-2-carbonitrile 

Downstream Products

• 1615720-26-7 C₁₉H₁₄N₄O₄S 
• 1615720-27-8 C₁₉H₁₄N₄O₄S 
• 1208072-08-5 C₁₉H₁₆N₄O₃S 
• 1208072-09-6 C₁₉H₁₆N₄O₃S 
• 1208072-02-9 C₁₉H₁₆N₄O₂S 
• 1208072-96-1 C₂₄H₁₉N₅O₂S 
• 1208071-77-5 C₁₈H₁₄N₄O₂S 
• 1208072-80-3 C₁₇H₁₁N₃O₃S 

Relevant articles and documents

COMPOUNDS FOR TREATING HUNTINGTON'S DISEASE

The present description relates to compounds, forms, and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease. In particular, the present description relates to substituted monocyclic heteroaryl compounds of Formula (I), Formula (II), or Formula (III), forms and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease.

PYRIDINYL PYRAZOLES AS MODULATORS OF RORyT

The present invention comprises compounds of Formula I. wherein: R1, R3, R4, R5, R6, and Q are defined in the specification. The invention also comprises a method of treating or ameliorating a ROR-γ-t mediated syndrome, disorder or disease, including wherein the syndrome, disorder or disease is selected from the group consisting of rheumatoid arthritis, psoriatic arthritis, and psoriasis. The invention also comprises a method of modulating RORγt activity in a mammal by administration of a therapeutically effective amount of at least one compound of Formula I.

TBK/IKK INHIBITOR COMPOUNDS AND USES THEREOF

The present invention relates to compounds of Formula I and pharmaceutically acceptable compositions thereof, useful as TBK/IKKε inhibitors.