1208076-70-3

Usage

Uses

Used in Pharmaceutical Industry:
2-BROMO-4-METHYLTHIOBENZAMIDE is used as a key intermediate in the synthesis of pharmaceuticals for its ability to inhibit soluble epoxide hydrolase, which can contribute to the development of treatments targeting blood pressure and inflammation-related conditions.
Used in Agrochemical Industry:
In the agrochemical sector, 2-BROMO-4-METHYLTHIOBENZAMIDE is utilized as an intermediate in the production of agrochemicals, potentially aiding in the creation of more effective pesticides and other agricultural chemicals.
Used in Dye and Pigment Industry:
2-BROMO-4-METHYLTHIOBENZAMIDE is employed as an intermediate in the synthesis of dyes and pigments, contributing to the development of a diverse range of colorants for various applications.
Used in Research and Development:
2-BROMO-4-METHYLTHIOBENZAMIDE is also used in research and development settings for studying the effects of soluble epoxide hydrolase inhibition and exploring its potential applications in medicine and other fields.

Upstream product

• 131002-03-4 4-methyl-2- bromobenzamide 

Downstream Products

• 1415718-91-0 C₁₇H₁₄BrNOS 
• 1334212-46-2 3,5-bis(2-bromo-4-methylphenyl)-1,2,4-thiadiazole 

Relevant academic research and scientific papers

Method for synthesizing thiobenzamide derivative through CO2 regulation and control of substituted benzonitrile

The invention discloses a method for synthesizing a thiobenzamide derivative through CO2 regulation and control of substituted benzonitrile. The method comprises the following steps: taking the substituted benzonitrile as a raw material, an inorganic sulfide as a sulfur source and CO2 as an auxiliary agent for reacting in the presence of a reaction solvent, and concentrating and purifying a reaction solution to obtain the thiobenzamide derivative. The reaction system disclosed by the invention is relatively simple, other catalysts are not added outside a reactant and the inorganic sulfide, themethod is suitable for synthesis of high-additional-value thiobenzamide containing a plurality of substituent groups, the reaction is carried out at low temperature and low pressure, and the risk coefficient is reduced.

Optimizing thiadiazole analogues of resveratrol versus three chemopreventive targets

Chemoprevention is an approach to decrease cancer morbidity and mortality through inhibition of carcinogenesis and prevention of disease progression. Although the trans stilbene derivative resveratrol has chemopreventive properties, its action is compromised by weak non-specific effects on many biological targets. Replacement of the stilbene ethylenic bridge of resveratrol with a 1,2,4-thiadiazole heterocycle and modification of the substituents on the two aromatic rings afforded potential chemopreventive agents with enhanced potencies and selectivities when evaluated as inhibitors of aromatase and NF-κB and inducers of quinone reductase 1 (QR1).