1208081-99-5

Basic information

• Product Name: 4-(3-Cyano-pyridin-2-yl)-benzoic acid ethyl ester
• Synonyms: 4-(3-Cyano-pyridin-2-yl)-benzoic acid ethyl ester;Ethyl 4-(3-cyanopyridin-2-yl)benzoate
• CAS NO: 1208081-99-5
• Molecular Formula: C₁₅H₁₂N₂O₂
• Molecular Weight: 252.26798
• Mol File: 1208081-99-5.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-(3-Cyano-pyridin-2-yl)-benzoic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(3-Cyano-pyridin-2-yl)-benzoic acid ethyl ester(1208081-99-5)
• EPA Substance Registry System: 4-(3-Cyano-pyridin-2-yl)-benzoic acid ethyl ester(1208081-99-5)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 1208081-99-5(Hazardous Substances Data)

Upstream product

• 100-54-9 pyridine-3-carbonitrile 
• 219766-02-6 2-(methylthio)nicotinonitrile 
• 6602-54-6 2-chloro-3-pyridinecarbonitrile 

Relevant articles and documents

Arylation, Vinylation, and Alkynylation of Electron-Deficient (Hetero)arenes Using Iodonium Salts

Arylation, vinylation, and alkynylation of electron-deficient arenes and heteroarenes have been achieved by chemoselective C-H zincation followed by copper-catalyzed coupling reactions using iodonium salts. This approach offers a direct and general access to a wide scope of (hetero)biaryls as well as alkenylated and alkynylated heteroarenes under mild conditions. It is particularly useful and valuable for the rapid and modular synthesis of diverse (hetero)aryl compounds, as demonstrated in the synthesis of transient receptor potential vanilloid 1 (TRPV1) antagonists and angiotensin II receptor type 1 (AT1 receptor) antagonists.