1208092-27-6

Basic information

• Product Name: [(S)-(+)-5,5'-bis(diphenylphosphino)-4,4'-bi-1,3-benzodioxole][4-cyano-3-nitrobenzenecarboxylato] [1,2,3-eta-2-propenyl Ir(III)]
• CAS NO: 1208092-27-6
• Molecular Weight: 1033.99
• Mol File: 1208092-27-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: [(S)-(+)-5,5'-bis(diphenylphosphino)-4,4'-bi-1,3-benzodioxole][4-cyano-3-nitrobenzenecarboxylato] [1,2,3-eta-2-propenyl Ir(III)](CAS DataBase Reference)
• NIST Chemistry Reference: [(S)-(+)-5,5'-bis(diphenylphosphino)-4,4'-bi-1,3-benzodioxole][4-cyano-3-nitrobenzenecarboxylato] [1,2,3-eta-2-propenyl Ir(III)](1208092-27-6)
• EPA Substance Registry System: [(S)-(+)-5,5'-bis(diphenylphosphino)-4,4'-bi-1,3-benzodioxole][4-cyano-3-nitrobenzenecarboxylato] [1,2,3-eta-2-propenyl Ir(III)](1208092-27-6)

Safety Data

• Hazardous Substances Data: 1208092-27-6(Hazardous Substances Data)

Usage

Reactions

Catalyst used for the diastereo- and enantioselective carbonyl (trimethylsilyl)allylation from the alcohol, or aldehyde, oxidation level. Catalyst used for the diastereo- and enantioselective carbonyl (hydroxy)allylation to form anti-1,2-diols. Catalyst used for the diastereo- and enantioselective carbonyl (hydroxymethyl)allylation from the alcohol, or aldehyde, oxidation level. Catalyst used for the diastereo- and enantioselective carbonyl tert-prenylation from the alcohol, or aldehyde, oxidation level. Catalyst used for the diastereo- and enantioselective carbonyl double crotylation of 1,3-diols. Catalyst used for the diastereo- and enantioselective carbonyl crotylation from the alcohol or aldehyde oxidation level

Upstream product

• 12112-67-3 bis(1,5-cyclooctadiene)diiridium(I) dichloride 
• 591-87-7 Allyl acetate 
• 210169-54-3 (S)-SEGPHOS 
• 153775-42-9 2-nitro-4-carboxybenzonitrile 

Relevant articles and documents

Enantioselective Synthesis of des-Epoxy-Amphidinolide N

The synthesis of des-epoxy-amphidinolide N was achieved in 22 longest linear and 33 total steps. Three generations of synthetic endeavors are reported herein. During the first generation, our key stitching strategy that highlighted an intramolecular Ru-catalyzed alkene-alkyne (Ru AA) coupling and a late-stage epoxidation proved successful, but the installation of the α,α′-dihydroxyl ketone motif employing a dihydroxylation method was problematic. Our second generation of synthetic efforts addressed the scalability problem of the southern fragment synthesis and significantly improved the efficiency of the atom-economical Ru AA coupling, but suffered from several protecting group-based issues that proved insurmountable. Finally, relying on a judicious protecting group strategy together with concise fragment preparation, des-epoxy-amphidinolide N was achieved in a convergent fashion. Calculations disclose a hydrogen-bonding bridge within amphidinolide N. Comparisons of 13C NMR chemical shift differences using our synthetic des-epoxy-amphidinolide N suggest that amphidinolide N and carbenolide I are probably identical.

Total synthesis of (+)-roxaticin via C-C bond forming transfer hydrogenation: A departure from stoichiometric chiral reagents, auxiliaries, and premetalated nucleophiles in polyketide construction

A total synthesis of the oxo-polyene macrolide (+)-roxaticin is achieved in 20 steps from 1,3-propanediol. In this approach, 9 of 10 C-C bonds formed in the longest linear sequence are made via metal catalysis, including 7 C-C bonds formed by iridium cata