1208111-49-2Relevant academic research and scientific papers
Copper-Catalyzed [2 + 2 + 3] Annulation of 1,6-Enynes with α-Bromo-1,3-Dicarbonyl Compounds: Synthesis of Dihydrooxepines
Zheng, Lan,Liang, Yong-Min
, p. 7000 - 7007 (2017)
Copper-catalyzed [2 + 2 + 3] annulation of 1,6-enynes with α-bromo-1,3-dicarbonyl compounds is described. This reaction provides facile access to seven-membered dihydrooxepines for epidithiodiketopiperazines with two newly formed C-C bonds and one C-O bon
Alkene: Versus alkyne reactivity in unactivated 1,6-enynes: Regio-And chemoselective radical cyclization with chalcogens under metal-And oxidant-free conditions
Kudale, Vishal Suresh,Li, Jing,Mutra, Mohana Reddy,Tsai, Wu-Hsun,Wang, Jeh-Jeng
, p. 2288 - 2300 (2020/04/21)
Herein, we have developed metal and oxidant-free visible light-promoted alkene vs. alkyne regio-And chemoselective radical cascade cyclization of electronically unbiased 1,6-enynes with chalcogens to synthesize substituted pyrrolidines bearing chalcogens. The reaction generated three new bonds, namely, C-SO2, C-C, and C-Se under extremely mild conditions. Furthermore, we achieved regio-And chemoselective mono-addition of aromatic thiophenols with unactivated 1,6-enynes. The key features of this protocol are broad substrate scope, environment-friendly conditions, operational simplicity, atom economy, and amenability to gram-scale synthesis. The mechanistic studies corroborate that the reaction proceeds via a radical pathway.
Regio- And chemoselective synthesis of nitrogen-containing heterocycles: Via the oxidative cascade cyclization of unactivated 1, n -enynes
Mutra, Mohana Reddy,Dhandabani, Ganesh Kumar,Li, Jing,Wang, Jeh-Jeng
, p. 2051 - 2054 (2020/02/22)
The development of a method for performing radical initiated intramolecular cascade cyclization of 1,n-enynes provided a competent protocol for producing structurally diverse complex heterocycles. Herein, we demonstrate I2/TBHP promoted, solven
Synthesis of Chlorotrifluoromethylated Pyrrolidines by Electrocatalytic Radical Ene-Yne Cyclization
Ye, Ke-Yin,Song, Zhidong,Sauer, Gregory S.,Harenberg, Johannes H.,Fu, Niankai,Lin, Song
supporting information, p. 12274 - 12279 (2018/08/31)
The stereoselective synthesis of chlorotrifluoromethylated pyrrolidines was achieved using anodically coupled electrolysis, an electrochemical process that combines two parallel oxidative events in a convergent and productive manner. The bench-stable and
Copper-catalyzed three-component cyanotrifluoromethylation/ azidotrifluoromethylation and carbocyclization of 1,6-enynes
He, Yu-Tao,Li, Lian-Hua,Zhou, Zhao-Zhao,Hua, Hui-Liang,Qiu, Yi-Feng,Liu, Xue-Yuan,Liang, Yong-Min
supporting information, p. 3896 - 3899 (2014/08/18)
A novel three-component strategy for the cyanotrifluoromethylation/ azidotrifluoromethylation and carbocyclization of 1,6-enynes is developed. The reaction proceeds smoothly under a moderate temperature by using a copper catalyst, which provides a rapid a
Lewis acid mediated intramolecular C-C bond formation of alkyne-epoxide leading to six-membered nitrogen and oxygen heterocycles
Ghosh, Priya,Saha, Pipas,Bondalapati, Somasekhar,Indukuri, Kiran,Saikia, Anil K.
, p. 4119 - 4124 (2014/05/20)
Intramolecular C-C bond formation of oxygen- and nitrogen-tethered alkynes and epoxide mediated by Lewis acid under ambient conditions is described. A simple procedure for the synthesis of 3,6- and 5,6-dihydropyrans and 3,4-dehydropiperidines from acyclic
Rhodium(I)-catalyzed cycloisomerization of 1,6-enynes to bicyclo[4.1.0]heptenes
Kim, Sun Young,Chung, Young Keun
supporting information; experimental part, p. 1281 - 1284 (2010/04/29)
(Chemical Equation Presented) Efficient rhodium(I)-catalyzed cyclopropanation reactions of nitrogen-tethered 1,6-enynes to azabicyclo[4.1.0]heptenes are reported. Moreover, rhodium(I)-catalyzed tandem cycloisomerization and carbonylative [3+3+1] cycloaddition reactions of a cyclopropylenyne have been observed. 2010 American Chemical Society.
