1208114-08-2

Upstream product

• 5532-86-5 benzyl cyanoformate 
• 7292-73-1 (2RS)-N-(p-fluorophenyl)glycine 

Downstream Products

• 1208114-38-8 5-(4-fluorophenyl)-2-(trifluoromethyl)-1H-imidazole-4-carboxylic acid 
• 1422175-69-6 C₂₃H₁₄F₄N₆O₃ 
• 1422175-68-5 C₂₄H₁₇F₄N₅O₃ 
• 1422175-67-4 C₂₆H₁₈F₄N₆O₂ 
• 1422175-65-2 C₂₆H₁₈F₄N₆O₂ 
• 1422175-64-1 C₂₄H₁₇F₄N₅O₂ 
• 1422175-63-0 C₂₄H₁₇F₄N₅O₂ 
• 1422175-62-9 (5-{[5-(4-fluorophenyl)-2-trifluoromethyl-3H-imidazole-4-carbonyl]amino}-2-methylphenyl)amine 
• 1422175-61-8 (5-{ [5-(4-fluorophenyl)-2-trifluoromethyl-3H-imidazole-4-carbonyl]amino}-2-methyl-phenyl)carbamic acid tert-butyl ester 
• 1422175-60-7 5-(4-fluoro-phenyl)-2-trifluoromethyl-3H-imidazole-4-carboxylic acid [3-(3-aminopyrazin-2-yl-oxymethyl)-4-chlorophenyl]amide 
• 1422175-59-4 C₂₃H₁₄ClF₄N₅O₂ 
• 1422175-58-3 C₂₃H₁₄ClF₄N₅O₂ 
• 1422175-57-2 C₂₃H₁₄ClF₄N₅O₂ 
• 1422176-19-9 C₁₈H₁₂ClF₄N₃O₂ 

Relevant academic research and scientific papers

PREPARATION AND METHODS OF USE FOR ORTHO-ARYL 5- MEMBERED HETEROARYL-CARBOXAMIDE CONTAINING MULTI-TARGETED KINASE INHIBITORS

The present disclosure relates to compounds of the Formula (I): and pharmaceutically acceptable salts, as kinase modulators, compatible with the Type-II inhibition of kinases.

Application of a novel [3+2] cycloaddition reaction to prepare substituted imidazoles and their use in the design of potent DFG-out allosteric B-Raf inhibitors

B-Raf protein kinase, which is a key signaling molecule in the RAS-RAF-MEK-ERK signaling pathway, plays an important role in many cancers. The B-Raf V600E mutation represents the most frequent oncogenic kinase mutation known and is responsible for increas