1208127-13-2Relevant academic research and scientific papers
Visible-light photocatalytic aerobic annulation for the green synthesis of pyrazoles
Ding, Ya,Zhang, Te,Chen, Qiu-Yun,Zhu, Chunyin
supporting information, p. 4206 - 4209 (2016/09/09)
A selective and high yielding synthesis of polysubstituted pyrazoles through a VLPC (visible light photoredox catalysis)-promoted reaction of hydrazine with Michael acceptors is reported. The method employs very mild reaction conditions and uses air as the terminal oxidant, which makes the process environmentally benign. Different types of Michael acceptors with various substituents can undergo the reaction to afford corresponding pyrazoles in good to excellent yields. The reaction is proposed to go through VLPC-promoted oxidation of hydrazine to diazene followed by its addition to Michael acceptors, other than the conventional condensation of hydrazine with a carbonyl.
Multi-Step synthesis by using modular flow reactors: The preparation of Yne-Ones and their use in heterocycle synthesis
Baxendale, Ian R.,Schou, Seren C.,Sedelmeier, Joerg,Ley, Steven V.
supporting information; experimental part, p. 89 - 94 (2010/03/03)
"Chemical Equation Presented" Multi-step in flow: The palladium-catalysed acylation of terminal alkynes for the synthesis of yne-ones as well as their further transformation to various heterocycles in a continuous-flow mode is presented. Furthermore, an extension of the simple flow configuration that allows for easy batch splitting and the generation of a heterocyclic library is described (see scheme).
