53692-59-4

Upstream product

• 536-74-3 phenylacetylene 
• 591-18-4 1-Bromo-3-iodobenzene 
• 201230-82-2 carbon monoxide 
• 2170-06-1 1-Phenyl-2-(trimethylsilyl)acetylene 
• 3132-99-8 m-bromobenzoic aldehyde 
• 1711-09-7 3-bromobenzoyl chloride 
• 278168-68-6 1-(3-bromophenyl)-3-phenylprop-2-yn-1-ol 

Downstream Products

• 67005-25-8 (Z)-3-Benzylsulfanyl-1-(3-bromo-phenyl)-3-phenyl-propenone 
• 928843-00-9 2-(3-bromophenyl)-2-(2-phenylethynyl)-1,3-dithiolane 
• 1155423-96-3 2-(3-bromophenyl)-2-(phenylethynyl)-1,3-dithiane 
• 1208127-13-2 3-(3-bromophenyl)-1-methyl-5-phenyl-1H-pyrazole 
• 1315379-39-5 dimethyl 4-bromo-1-oxo-3-phenyl-1H-inden-2-ylphosphonate 
• 1315379-33-9 dimethyl 6-bromo-1-oxo-3-phenyl-1H-inden-2-ylphosphonate 
• 25856-02-4 1-(3-bromophenyl)-3-phenylpropane-1,3-dione 
• 100-47-0 benzonitrile 
• 86175-33-9 (E)-1-(3-Bromo-phenyl)-3-phenyl-3-p-tolylsulfanyl-propenone 
• 86175-32-8 (Z)-1-(3-Bromo-phenyl)-3-phenyl-3-p-tolylsulfanyl-propenone 

Relevant academic research and scientific papers

Organoborane-catalyzed selective 1,2-reduction of alkynones with hydride transfer: Synthesis of benzyl alkynes

Benzyl alkynes are important organic building blocks in organic synthesis. We report herein a B(C6F5)3-catalyzed site-selective 1,2-reduction of readily available alkynones to access benzyl alkyne derivatives. Under the de

Carbonylative Sonogashira Coupling of Aryl Iodides with Terminal Alkynes Catalyzed by Palladium Nanoparticles

A convenient and efficient method for the synthesis of α,β-alkynyl ketones from the three-component coupling of aryl iodides, terminal alkynes, and carbon monoxide (carbonylative Sonogashira coupling reaction) is successfully developed. The carbonylative Sonogashira coupling reaction proceeded smoothly under mild conditions in the presence of palladium nanoparticles to produce the corresponding α,β-alkynyl ketones in good to excellent yields.

An effective preparation of both 1,3-diketones and nitriles from alkynones with oximes as hydroxide sources

An effective phosphine-catalyzed protocol has been established for the syntheses of 1,3-diketones and nitriles from alkynones with oximes as hydroxide surrogates. This method features the use of a phosphine catalyst, compatibility with various functional groups and ambient temperature, which makes this approach very practical. A plausible mechanism was proposed.

Alkynylation of Csp2 (O)–H Bonds Enabled by Photoredox-Mediated Hydrogen-Atom Transfer

The development of new hydrogen-atom transfer (HAT) strategies within the framework of photoredox catalysis is highly appealing for its power to activate a desired C?H bond in the substrate leading to its selective functionalization. Reported here is the first photoredox-mediated hydrogen-atom transfer method for the efficient synthesis of ynones, ynamides, and ynoates with high regio- and chemoselectivity by direct functionalization of Csp2 (O)?H bonds. The broad synthetic application of this method has been demonstrated by the selective functionalization of C(O)?H bonds within complex molecular scaffolds.

METABOTROPIC GLUTAMATE RECEPTOR NEGATIVE ALLOSTERIC MODULATORS (NAMS) AND USES THEREOF

Provided herein are small molecule active metabotropic glutamate subtype-2 and -3 receptor negative allosteric modulators (NAMs), compositions comprising the compounds, and methods of using the compounds and compositions.

Synthesis of phosphonylated and thiolated indenones by manganese(III)- mediated addition of phosphorus- and sulfur-centered radicals to 1,3-diarylpropynones

Phosphorus- or sulfur-centered radicals generated from the reaction of manganese(III) acetate with dialkyl phosphonates or arylthiols undergo selective additions to conjugated alkynes followed by cyclization and rearomatization to afford 2-phosphonyl- or

Multi-Step synthesis by using modular flow reactors: The preparation of Yne-Ones and their use in heterocycle synthesis

"Chemical Equation Presented" Multi-step in flow: The palladium-catalysed acylation of terminal alkynes for the synthesis of yne-ones as well as their further transformation to various heterocycles in a continuous-flow mode is presented. Furthermore, an extension of the simple flow configuration that allows for easy batch splitting and the generation of a heterocyclic library is described (see scheme).

Au(PPh3)Cl-AgSbF6-catalyzed rearrangement of propargylic 1,3-dithianes: Formation of 8-membered 1,3-bisthio-substituted cyclic allenes

Au(PPh3)Cl-AgSbF6-catalyzed rearrangement of propargylic 1,3-dithiane leads to the formation of 8-membered dithio-substituted cyclic allenes, which are remarkably stable. The Royal Society of Chemistry 2009.

Au-catalyzed reaction of propargylic sulfides and dithioacetals

(Chemical Equation Presented) Propargylic sulfides and dithioacetals are found to undergo similar transformations as propargylic carboxylates when catalyzed by AuCl or AuCl3, affording indene derivatives through pentannulation of aromatic rings