1208162-98-4 Usage
General Description
H-N-Me-D-Leu-OBzl·TosOH, also known as N-Methyl-D-Leucine benzyl ester tosylate, is a chemical compound used in organic synthesis and pharmaceutical research. It is a derivative of the amino acid leucine, with a methyl group attached to the nitrogen atom and a benzyl ester group attached to the carboxylic acid functional group. The tosylate salt form of the compound is commonly used in chemical reactions as a protecting group for the amine functionality. It is used in the synthesis of peptide and protein-based drugs, as well as in the production of other bioactive molecules. N-Methyl-D-Leucine benzyl ester tosylate is an important tool for synthetic chemists and researchers working in the fields of medicinal chemistry and drug discovery.
Check Digit Verification of cas no
The CAS Registry Mumber 1208162-98-4 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,0,8,1,6 and 2 respectively; the second part has 2 digits, 9 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 1208162-98:
(9*1)+(8*2)+(7*0)+(6*8)+(5*1)+(4*6)+(3*2)+(2*9)+(1*8)=134
134 % 10 = 4
So 1208162-98-4 is a valid CAS Registry Number.
InChI:InChI=1S/C14H21NO2.C7H8O3S/c1-11(2)9-14(3,15)13(16)17-10-12-7-5-4-6-8-12;1-6-2-4-7(5-3-6)11(8,9)10/h4-8,11H,9-10,15H2,1-3H3;2-5H,1H3,(H,8,9,10)/t14-;/m1./s1
1208162-98-4Relevant articles and documents
MW-enhanced high-speed deprotection of Boc group using p-TsOH and concommitant formation of N-Me-amino acid benzyl ester p-TsOH salts
Suresh Babu, Vommina V.,Patil, Basanagoud S.,Vasanthakumar, Ganga-Ramu
, p. 1795 - 1802 (2007/10/03)
A high-speed, complete deprotection of Boc group from Boc amino acids and protected peptide esters employing p-TsOH in toluene under microwave irradiation is found to be complete in 30s. The deprotection can be carried out in methanol and acetonitrile also. Under the present conditions, C-peptide benzyl esters and O-benzyl ethers have been found to be stable. This has permitted us to carry out the synthesis of [Leu]enkephalin employing the Boc/Bzl-group strategy. Further more, it has been found that both Nα-Fmoc and N α-Z groups are completely stable. The present conditions can be extended for the concomitant removal of the Boc group and the formation of C-benzyl amino acid esters as well. This has been utilized for the synthesis of N-Me amino acid benzyl esters starting from Boc-N-Me amino acids in a single step. Copyright Taylor & Francis, Inc.
