1208162-98-4 Usage
Uses
Used in Pharmaceutical Research and Organic Synthesis:
H-N-Me-D-Leu-OBzl·TosOH is used as a protecting group in chemical reactions for the amine functionality, which is crucial for the synthesis of complex organic molecules and pharmaceutical compounds. Its role in protecting the amine group allows for selective reactions to occur at other sites on the molecule, facilitating the creation of specific drug candidates and bioactive molecules.
Used in Peptide and Protein-based Drug Synthesis:
In the synthesis of peptide and protein-based drugs, H-N-Me-D-Leucine benzyl ester tosylate is employed as a key component. Its structural features enable the formation of peptide bonds, which are the building blocks of proteins. H-N-Me-D-Leu-OBzl·TosOH contributes to the development of therapeutic peptides and proteins that can be used for treating various diseases and medical conditions.
Used in Medicinal Chemistry and Drug Discovery:
H-N-Me-D-Leu-OBzl·TosOH is utilized as a valuable tool in medicinal chemistry and drug discovery. Its unique properties and reactivity make it suitable for the design and synthesis of novel drug candidates. Researchers can leverage H-N-Me-D-Leu-OBzl·TosOH to explore new chemical space and develop innovative therapeutic agents with improved efficacy and selectivity.
Check Digit Verification of cas no
The CAS Registry Mumber 1208162-98-4 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,0,8,1,6 and 2 respectively; the second part has 2 digits, 9 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 1208162-98:
(9*1)+(8*2)+(7*0)+(6*8)+(5*1)+(4*6)+(3*2)+(2*9)+(1*8)=134
134 % 10 = 4
So 1208162-98-4 is a valid CAS Registry Number.
InChI:InChI=1S/C14H21NO2.C7H8O3S/c1-11(2)9-14(3,15)13(16)17-10-12-7-5-4-6-8-12;1-6-2-4-7(5-3-6)11(8,9)10/h4-8,11H,9-10,15H2,1-3H3;2-5H,1H3,(H,8,9,10)/t14-;/m1./s1
1208162-98-4Relevant articles and documents
MW-enhanced high-speed deprotection of Boc group using p-TsOH and concommitant formation of N-Me-amino acid benzyl ester p-TsOH salts
Suresh Babu, Vommina V.,Patil, Basanagoud S.,Vasanthakumar, Ganga-Ramu
, p. 1795 - 1802 (2007/10/03)
A high-speed, complete deprotection of Boc group from Boc amino acids and protected peptide esters employing p-TsOH in toluene under microwave irradiation is found to be complete in 30s. The deprotection can be carried out in methanol and acetonitrile also. Under the present conditions, C-peptide benzyl esters and O-benzyl ethers have been found to be stable. This has permitted us to carry out the synthesis of [Leu]enkephalin employing the Boc/Bzl-group strategy. Further more, it has been found that both Nα-Fmoc and N α-Z groups are completely stable. The present conditions can be extended for the concomitant removal of the Boc group and the formation of C-benzyl amino acid esters as well. This has been utilized for the synthesis of N-Me amino acid benzyl esters starting from Boc-N-Me amino acids in a single step. Copyright Taylor & Francis, Inc.
