89536-84-5 Usage
General Description
Boc-N-methyl-D-leucine is a chemical compound that belongs to the class of N-protected amino acids. It is a derivative of the amino acid leucine, with a Boc (tert-butoxycarbonyl) group attached to the amino group and a methyl group attached to the alpha carbon. Boc-N-methyl-D-leucine is often used as a building block for the synthesis of peptides and peptidomimetics. It can be used to introduce the N-methyl-D-leucine moiety into peptide chains, which can modulate the structure and properties of the resulting peptide. Boc-N-methyl-D-leucine can also be utilized in the study of protein structure and function, as well as in the development of pharmaceuticals and bioactive compounds targeting specific protein-protein interactions.
Check Digit Verification of cas no
The CAS Registry Mumber 89536-84-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,9,5,3 and 6 respectively; the second part has 2 digits, 8 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 89536-84:
(7*8)+(6*9)+(5*5)+(4*3)+(3*6)+(2*8)+(1*4)=185
185 % 10 = 5
So 89536-84-5 is a valid CAS Registry Number.
InChI:InChI=1/C12H23NO4/c1-8(2)7-9(10(14)15)13(6)11(16)17-12(3,4)5/h8-9H,7H2,1-6H3,(H,14,15)/t9-/m1/s1
89536-84-5Relevant articles and documents
Preparation method of N-trimethyl silicon ethoxycarbonyl-N-methyl-L/D-leucine
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Paragraph 0084; 0087; 0090; 0093, (2021/06/02)
The invention relates to a preparation method of N-(trimethylsilyl) ethoxycarbonyl group-N-methyl-L/D-leucine. The preparation method comprises the following steps: adding N-methyl-L/D-leucine hydrochloride, a trimethylsilylethoxycarbonyl protecting group reagent and alkali into a mixed solution of a polar solvent and water, and carrying out a reaction, so as to obtain the N-trimethylsilylethoxycarbonyl-N-methyl-L/D-leucine. According to the preparation method, the N-trimethyl silicon ethoxycarbonyl-N-methyl-L/D-leucine with high chiral purity, high chemical purity and high yield can be obtained, the chiral purity and the chemical purity can reach 99% or above, the yield can reach 60% or above, and the preparation method is simple in process, mild in condition and suitable for being applied to large-scale industrial production.
HETEROCYCLIC KINASE INHIBITORS
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Page/Page column 104, (2016/05/19)
The present disclosure is generally directed to compounds which can inhibit AAK1 (adaptor associated kinase 1), compositions comprising such compounds, and methods for inhibiting AAK1.