1208222-39-2 Usage
Uses
Used in Pharmaceutical Industry:
VU 0365114 is used as a selective positive allosteric modulator for the M5 receptor, which may have potential therapeutic applications in treating various medical conditions. The selective modulation of the M5 receptor could provide targeted treatment options with reduced side effects compared to non-selective modulators.
Used in Research Applications:
VU 0365114 is used as a research tool to study the role and function of the M5 receptor in various biological processes. The selective modulation of the M5 receptor allows researchers to investigate its specific interactions and signaling pathways, contributing to a better understanding of its potential therapeutic applications.
Used in Drug Development:
VU 0365114 serves as a lead compound in the development of new drugs targeting the M5 receptor. Its selective modulation of the M5 receptor can be further optimized and modified to create more potent and effective drugs for treating specific medical conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 1208222-39-2 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,0,8,2,2 and 2 respectively; the second part has 2 digits, 3 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 1208222-39:
(9*1)+(8*2)+(7*0)+(6*8)+(5*2)+(4*2)+(3*2)+(2*3)+(1*9)=112
112 % 10 = 2
So 1208222-39-2 is a valid CAS Registry Number.
1208222-39-2Relevant academic research and scientific papers
Chemical lead optimization of a pan Gq mAChR M1, M3, M5 positive allosteric modulator (PAM) lead. Part I: Development of the first highly selective M5 PAM
Bridges, Thomas M.,Kennedy, J. Phillip,Cho, Hyekyung P.,Breininger, Micah L.,Gentry, Patrick R.,Hopkins, Corey R.,Conn, P. Jeffrey,Lindsley, Craig W.
scheme or table, p. 558 - 562 (2010/08/06)
This Letter describes a chemical lead optimization campaign directed at VU0238429, the first M5-preferring positive allosteric modulator (PAM), discovered through analog work around VU0119498, a pan Gq mAChR M1, M3, M5 PAM. An iterative library synthesis approach delivered the first selective M5 PAM (no activity at M1-M4 @ 30 μM), and an important tool compound to study the role of M5 in the CNS.
