1208308-08-0Relevant academic research and scientific papers
Novel imidazolopyrimidines as dual PI3-Kinase/mTOR inhibitors
Venkatesan, Aranapakam M.,Dehnhardt, Christoph M.,Chen, Zecheng,Santos, Efren Delos,Dos Santos, Osvaldo,Bursavich, Matthew,Gilbert, Adam M.,Ellingboe, John W.,Ayral-Kaloustian, Semiramis,Khafizova, Gulnaz,Brooijmans, Natasja,Mallon, Robert,Hollander, Irwin,Feldberg, Larry,Lucas, Judy,Yu, Ker,Gibbons, Jay,Abraham, Robert,Mansour, Tarek S.
scheme or table, p. 653 - 656 (2010/07/05)
This article describes the syntheses and SAR of a series of imidazolopyrimidine derivatives, which are evaluated as inhibitors of PI3-Kinase (PI3 K) and mTOR. These compounds were found to be ATP competitive with good tumor cell growth inhibition, and suppression of pathway specific biomakers such as phosphorylation of Akt at T308.
