113118-82-4

Basic information

• Product Name: 5-CHLORO-PYRIDINE-3-CARBALDEHYDE
• Synonyms: 5-CHLORO-PYRIDINE-3-CARBALDEHYDE;5-Chloropyridine-3-carboxaldehyde;3-Pyridinecarboxaldehyde,5-chloro-(9CI);5-Chloronicotinaldehyde;5-Chloro-3-formylpyridine;5-Chloropyridine-3-carboxaldehyde, 5-Chloro-3-formylpyridine;5-chloropyridin-3-carbaldehyde;5-chloro-3-Pyridinecarboxaldehyde
• CAS NO: 113118-82-4
• Molecular Formula: C₆H₄ClNO
• Molecular Weight: 141.56
• EINECS: 1312995-182-4
• Product Categories: PYRIDINE;pharmacetical;Building Blocks
• Mol File: 113118-82-4.mol
• Article Data: 5

Chemical Properties

• Melting Point: 70-71°C
• Boiling Point: 226.026 °C at 760 mmHg
• Flash Point: 90.498 °C
• Appearance: /
• Density: 1.332 g/cm³
• Vapor Pressure: 0.084mmHg at 25°C
• Refractive Index: 1.593
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 1.15±0.20(Predicted)
• CAS DataBase Reference: 5-CHLORO-PYRIDINE-3-CARBALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-CHLORO-PYRIDINE-3-CARBALDEHYDE(113118-82-4)
• EPA Substance Registry System: 5-CHLORO-PYRIDINE-3-CARBALDEHYDE(113118-82-4)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22-36-43
• Safety Statements: 26-36/37
• RIDADR: UN2811
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 113118-82-4(Hazardous Substances Data)

Usage

General Description

5-CHLORO-PYRIDINE-3-CARBALDEHYDE is an organic compound with the chemical formula C7H5ClNO. It is a derivative of pyridine, containing a chlorine atom and an aldehyde functional group. This chemical is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It is also utilized in the production of dyes, pigments, and other organic compounds. 5-CHLORO-PYRIDINE-3-CARBALDEHYDE is a versatile building block in organic chemistry, valued for its reactivity and ability to participate in a wide range of chemical reactions. It is important to handle and store this compound with care, as it is a flammable and potentially hazardous substance.

InChI:InChI=1/C6H4ClNO/c7-6-1-5(4-9)2-8-3-6/h1-4H

Upstream product

• 85320-79-2 5-chloro-nicotinoyl chloride 
• 113118-73-3 3-Chloro-5-formyl-2H-pyridine-1-carboxylic acid phenyl ester 
• 22620-27-5 5-chloronicotinic acid 
• 22620-34-4 (5-chloro-pyridin-3-yl)-methanol 
• 113118-67-5 3-Chloro-2H-pyridine-1-carboxylic acid phenyl ester 
• 626-60-8 3-Chloropyridine 
• 20825-98-3 5-chloro-nicotinic acid ethyl ester 
• 117830-18-9 5-chloropyridine-3-carbohydrazide 
• 118420-18-1 C₁₃H₁₂ClN₃O₃S 

Downstream Products

• 1208308-08-0 C₂₆H₂₈ClN₇O₂ 
• 1410738-76-9 (3'R,4'R,5'R)-6''-chloro-4'-(5-chloropyridin-3-yl)-N-((1r,4R)-4-hydroxycyclohexyl)-2''-oxodispiro[cyclohexane-1,2'-pyrrolidine-3',3''-indoline]-5'-carboxamide 
• 1022156-49-5 2-(5-chloropyridin-3-yl)-8-oxo-9-(2-(trifluoromethyl)phenyl)-8,9-dihydro-7H-purine-6-carboxamide 
• 118420-36-3 (E)-N-[4-(4-Benzhydryl-piperazin-1-yl)-butyl]-3-(5-chloro-pyridin-3-yl)-acrylamide 

Relevant articles and documents

HETEROCYCLIC AMIDES AS KINASE INHIBITORS

Disclosed are compounds having the formula: (I) wherein R1, R2, and R3 are as defined herein, and methods of making and using the same.

Substituted 4-aryl-4h-pyrrolo[2,3-h]chromenes and analogs as activators of caspases and inducers of apoptosis and the use thereof

The present invention is directed to substituted 4H-chromenes and analogs thereof, represented by the Formula (I): wherein R1, R3-R5, A, D, Y and Z are defined herein. The present invention also relates to the discovery that compounds having Formula (I) are activators of caspases and inducers of apoptosis. Therefore, the activators of caspases and inducers of apoptosis of this invention can be used to induce cell death in a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.

SYNTHESIS OF SUBSTITUTED 3-PYRIDINECARBOXALDEHYDES

Treatment of 3-substituted 1-(phenoxycarbonyl)-1,2-dihydropyridines with Vilsmeier reagent (POCl3/DMF) gave 3-substituted 5-formyl-1-(phenoxycarbonyl)-1,2-dihydropyridines, which were aromatized with hot sulfur to provide 5-substituted 3-pyridinecarboxaldehydes. The formylation of 4-substituted 1-(phenoxycarbonyl)-1,4-dihydropyridines and subsequent aromatization gave 4-substituted 3-pyridinecarboxaldehydes.