120848-76-2

Basic information

• Product Name: (3,4-DIHYDRO-1H-ISOQUINOLIN-2-YL)-PIPERIDIN-4-YL-METHANONE
• Synonyms: 2-(piperidin-4-ylcarbonyl)-1,2,3,4-tetrahydroisoquinoline(SALTDATA: HCl);2-(PIPERIDIN-4-YLCARBONYL)-1,2,3,4-TETRAHYDROISOQUINOLINE;(3,4-DIHYDRO-1H-ISOQUINOLIN-2-YL)-PIPERIDIN-4-YL-METHANONE;AKOS BBV-004759;2-(piperidine-4-carbonyl)-1,2,3,4-tetrahydroisoquinoline
• CAS NO: 120848-76-2
• Molecular Formula: C₁₅H₂₀N₂O
• Molecular Weight: 244.33
• Mol File: 120848-76-2.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 437.5°C at 760 mmHg
• Flash Point: 218.4°C
• Appearance: /
• Density: 1.125g/cm³
• Vapor Pressure: 7.41E-08mmHg at 25°C
• Refractive Index: 1.567
• CAS DataBase Reference: (3,4-DIHYDRO-1H-ISOQUINOLIN-2-YL)-PIPERIDIN-4-YL-METHANONE(CAS DataBase Reference)
• NIST Chemistry Reference: (3,4-DIHYDRO-1H-ISOQUINOLIN-2-YL)-PIPERIDIN-4-YL-METHANONE(120848-76-2)
• EPA Substance Registry System: (3,4-DIHYDRO-1H-ISOQUINOLIN-2-YL)-PIPERIDIN-4-YL-METHANONE(120848-76-2)

Safety Data

• Hazardous Substances Data: 120848-76-2(Hazardous Substances Data)

Usage

Description

(3,4-DIHYDRO-1H-ISOQUINOLIN-2-YL)-PIPERIDIN-4-YL-METHANONE is a complex chemical compound characterized by a heterocyclic structure. It features a piperidine ring connected to a methanone group and a 3,4-dihydro-1H-isoquinolin-2-yl substituent. (3,4-DIHYDRO-1H-ISOQUINOLIN-2-YL)-PIPERIDIN-4-YL-METHANONE is notable for its potential pharmacological properties due to the presence of the piperidine moiety, which is a common feature in many biologically active substances.

Uses

Used in Pharmaceutical Research:
(3,4-DIHYDRO-1H-ISOQUINOLIN-2-YL)-PIPERIDIN-4-YL-METHANONE is used as a subject of pharmaceutical research for its potential to contribute to the development of new drugs. Its heterocyclic structure and the presence of a piperidine ring suggest that it may have biological activity, making it a candidate for further investigation and development.
Used in Drug Design:
In drug design, (3,4-DIHYDRO-1H-ISOQUINOLIN-2-YL)-PIPERIDIN-4-YL-METHANONE is utilized as a structural component in the creation of novel compounds with potential therapeutic applications. Its unique molecular features may allow for the design of drugs that target specific biological pathways or receptors.
Used in Chemical Synthesis:
(3,4-DIHYDRO-1H-ISOQUINOLIN-2-YL)-PIPERIDIN-4-YL-METHANONE serves as a key intermediate in chemical synthesis processes. Its complex structure can be further modified or used as a building block to synthesize a variety of other chemical compounds with different applications in research and industry.
Further studies and research are essential to fully explore the properties and potential applications of (3,4-DIHYDRO-1H-ISOQUINOLIN-2-YL)-PIPERIDIN-4-YL-METHANONE, as its current uses are based on its structural characteristics and the possibility of its pharmacological activity.

InChI:InChI=1/C15H20N2O/c18-15(13-5-8-16-9-6-13)17-10-7-12-3-1-2-4-14(12)11-17/h1-4,13,16H,5-11H2

Upstream product

• 91-21-4 1,2,3,4-tetrahydroisoquinoline 
• 126501-70-0 1-(2,2,2-trifluoroacetyl)piperidine-4-carboxylic acid 
• 280115-99-3 tert-butyl 4-(chlorocarbonyl)-piperidine-1-carboxylate 
• 84358-13-4 N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid 
• 350716-60-8 piperidine-1,4-dicarboxylic acid mono-(4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,11-heptadecafluoro-1,1-dimethylundecyl) ester 
• 498-94-2 isonipecotic acid 
• 350716-52-8 4-(3,4-dihydro-1H-isoquinoline-2-carbonyl)-piperidine-1-carboxylic acid 5,5,6,6,7,7,8,8,9,9,10,10,10-tridecafluoro-1-methyl-1-(4,4,5,5,6,6,7,7,8,8,9,9,9-tridecafluoro-nonyl)-decyl ester 
• 350716-46-0 4-(3,4-dihydro-1H-isoquinoline-2-carbonyl)piperidine-1-carboxylic acid 1-perfluorooctylethylisopropyl ester 
• 350716-56-2 4-(3,4-dihydro-1H-isoquinoline-2-carbonyl)-piperidine-1-carboxylic acid 5,5,6,6,7,7,8,8,8-nonafluoro-1-methyl-1-(4,4,5,5,6,6,7,7,7-nonafluoro-heptyl)-octyl ester 
• 350716-59-5 4-(3,4-dihydro-1H-isoquinolin-2-ylcarbonyl)piperidine-1,4-dicarboxylic acid 4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,11-heptadecafluoro-1,1-dimethyl-undecyl ester 

Downstream Products

• 120847-08-7 2-[(4-Piperidyl)methyl]-1,2,3,4-tetrahydroisoquinoline hydrochloride 
• 120847-08-7 2-(piperidin-4-ylmethyl)-1,2,3,4-tetrahydroisoquinoline dihydrochloride 
• 73415-60-8 (3,4-dihydro-1H-isoquinolin-2-yl)-piperidin-4-yl-methanone; hydrochloride 

Relevant articles and documents

Improving selectivity preserving affinity: New piperidine-4-carboxamide derivatives as effective sigma-1-ligands

We report the design, synthesis and binding evaluation against 1 and 2 receptors of a series of new piperidine-4-carboxamide derivatives variously substituted on the amide nitrogen atom. Specifically, we assessed the effects exerted on receptor affinity by substituting the N-benzylcarboxamide group present on a series of compounds previously synthesized in our laboratory with different cyclic or linear moieties. The synthesized compounds 2a-o were tested to estimate their affinity and selectivity toward 1 and2 receptors. Very high 1 affinity (Ki Combining double low line 3.7 nM) and Ki2/Ki1 selectivity ratio (351) were found for the tetrahydroquinoline derivative 2k, featuring a 4-chlorobenzyl moiety linked to the piperidine nitrogen atom.

2-((4-Piperidyl)methyl)-1,2,3,4-tetrahydroisoquinoline derivatives, their preparation and their application in therapy

A compound of formula (I) STR1 in which R is (a) a hydrogen atom; (b) a linear or branched (C1 -C6) alkyl group; an allyl group; a cycloalkylmethyl group in which the cycloalkyl moiety has from 3 to 6 carbon atoms; a phenylmethyl group unsubstituted or substituted with one to three substituents chosen from halogen atoms and trifluoromethyl, nitro, amino, dimethylamino, cyano, aminocarbonyl, linear or branched (C1 -C3) alkyl, linear or branched (C1 -C3) alkoxy and linear or branched (C1 -C3) alkylthio groups; a 2-phenylethyl group; a 3-phenylpropyl group; a 3-phenyl-2-propenyl group; a phenylcarbonylmethyl group; a naphthylmethyl group; a pyridylmethyl group; a furylmethyl group; or a thienylmethyl group; or (c) a linear or branched (C2 -C6) alkanoyl group; a cycloalkylcarbonyl group in which the cycloalkyl moiety has from 3 to 6 carbon atoms; a trifluoroacetyl group; a phenyl-carbonyl group unsubstituted or substituted with one to three substituents chosen from halogen atoms and trifluoromethyl, nitro, linear or branched (C1 -C3) alkyl, linear or branched (C1 -C3) alkoxy and linear or branched (C1 -C3) alkylthio groups; a 1-oxo-3-phenyl-2-propenyl group; a naphthylcarbonyl group; a pyridylcarbonyl group; a furylcarbonyl group; a thienylcarbonyl group; a (2-indolyl)-carbonyl group; or a (5-indolyl)carbonyl group; or a pharmacologically acceptable acid addition salt thereof.