1208610-06-3Relevant academic research and scientific papers
Ligand effects on the Pd-Catalyzed cross-coupling reaction of 3-Iodoalk-2-enoates with Propargyl/1,2-Allenylie metallic species: An efficient regiodivergent synthesis of 2,4,5-Trienoates
Zhao, Jinbo,Yu, Yihua,Ma, Shengming
supporting information; experimental part, p. 74 - 80 (2010/04/02)
"Chemical Equation Presented" A ligand makes a big difference : The 1,3-lithium shift of propargyl/1,2-allenyl lithium has been tuned and applied in a subsequent transmetalation and Pd-catalyzed Negishi coupling reaction with 3-iodoalk-2-enoates to give a highly regioselective and regiodivergent synthesis of 2,4,5-trienoates. It was discovered that ligands play a very important role in the cross-coupling reactions with respect to both regioselectivity and reactivity.
