73845-38-2

Upstream product

• 67-56-1 methanol 
• 201230-82-2 carbon monoxide 
• 10147-11-2 propargyl benzene 
• 75523-28-3 5-benzyl-1,2-dihydropyrazol-3-one 
• 103-80-0 phenylacetyl chloride 
• 37779-49-0 methyl 3-oxo-4-phenylbutanoate 
• 79-22-1 methyl chloroformate 
• 74268-63-6 Triphenylphosphin-phenacetyl-methoxycarbonyl-methylen 

Downstream Products

• 34541-75-8 methyl (Z)-4-phenyl-2-butenoate 
• 59554-14-2 (±)-(4R,5S)-4-benzyl-2-oxooxazolidine-5-carboxylic acid 
• 73845-40-6 methyl cis-2,3-epoxy-4-phenylbutanoate 
• 75443-87-7 methyl DL-threo-3-amino-2-hydroxy-4-phenylbutanoate 
• 120934-43-2 (E)Methyl 4-(3-methoxy-1-oxo-4-phenyl-2-butenyl)-2,5-dimethyl-1H-pyrrole-3-carboxylate 
• 1208610-06-3 methyl 3-iodo-4-phenylbut-2(Z)-enoate 

Relevant academic research and scientific papers

Ethylene Glycol Assisted Intermolecular Pauson-Khand Reaction

The use of ethylene glycol as additive in the N -oxide-promoted intermolecular Pauson-Khand reaction (PKR) has been studied. The addition of 15% ethylene glycol to the reaction mixture consistently increased (from 20% up to 2-4-fold) the reaction yields.

One-pot synthesis of trisubstituted monomethylated benzene-1,3-diols via a Michael addition-Dieckmann cyclization sequence from methyl (E)3-methoxy-4- methoxycarbonylbut-2-enoate anion and methyl alkynoates and its application to the total synthesis of nidulol

The reaction of methyl (E)3-methoxy-4-methoxycarbonylbut-2-enoate (1) with a number of methyl alkynoates under appropriate conditions gave the monomethylated trisubstituted resorcinol derivatives 3 in a regiocontrolled manner, via a Michael addition-Dieckmann cyclization sequence in one pot. The resorcinol 3d, prepared in this manner, was used as the starting material for a three step, highly efficient (54% from 3d) synthesis of the bioactive fungal metabolite nidulol (4). Georg Thieme Verlag Stuttgart.

Efficient preparative-scale procedures for the Pd-catalyzed methoxycarbonylation of acetylenes

A number of acetylenic esters RC≡C-COOCH3 have been prepared in good yields on a preparative scale by Pd-catalyzed methoxycarbonylation of acetylenes RC≡CH.