1208869-33-3

Basic information

• Product Name: C₂₁H₂₀N₄O₄S₂
• CAS NO: 1208869-33-3
• Molecular Weight: 456.546
• Mol File: 1208869-33-3.mol

Chemical Properties

• CAS DataBase Reference: C₂₁H₂₀N₄O₄S₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₁H₂₀N₄O₄S₂(1208869-33-3)
• EPA Substance Registry System: C₂₁H₂₀N₄O₄S₂(1208869-33-3)

Safety Data

• Hazardous Substances Data: 1208869-33-3(Hazardous Substances Data)

Upstream product

• 1208872-32-5 C₂₃H₂₄N₄O₄S₂ 
• 1208872-31-4 C₁₉H₁₉BrN₂O₄S₂ 
• 1208869-43-5 ethyl 7-(5-bromothiophen-2-yl)-4,7-dioxoheptanoate 
• 99866-37-2 C₁₁H₇BrO₂S 
• 5370-25-2 2-Acetyl-5-bromothiophene 
• 98-01-1 furfural 

Relevant articles and documents

Structure-activity relationship of pyrrole based S-nitrosoglutathione reductase inhibitors: Carboxamide modification

The enzyme S-nitrosoglutathione reductase (GSNOR) is a member of the alcohol dehydrogenase family (ADH) that regulates the levels of S-nitrosothiols (SNOs) through catabolism of S-nitrosoglutathione (GSNO). GSNO and SNOs are implicated in the pathogenesis of many diseases including those in respiratory, gastrointestinal, and cardiovascular systems. The pyrrole based N6022 was recently identified as a potent, selective, reversible, and efficacious GSNOR inhibitor which is currently in clinical development for acute asthma. We describe here the synthesis and structure-activity relationships (SAR) of novel pyrrole based analogs of N6022 focusing on carboxamide modifications on the pendant N-phenyl moiety. We have identified potent and novel GSNOR inhibitors that demonstrate efficacy in an ovalbumin (OVA) induced asthma model in mice.