1208989-34-7

Upstream product

• 529-20-4 2-methylphenyl aldehyde 
• 196929-78-9 (R)-2-methylpropane-2-sulfinamide 

Downstream Products

• 1133831-71-6 (R(S))-N-((R,E)-1-(2-methylphenyl)hex-2-enyl)-2-methylpropane-2-sulfinamide 
• 1198053-79-0 (1S,2R)-1-((R)-1,1-dimethylethylsulfinamido)-1-o-tolylbut-3-en-2-yl benzoate 
• 1208989-35-8 C₁₃H₁₈F₃NOS 
• 1256350-29-4 C₁₃H₁₅NO 
• 1415337-94-8 C₁₉H₂₂N₂OS₂ 
• 1585236-11-8 pinacol (R)-((R)-tert-butanesulfinamido)(2-methylphenyl)methylboronate 
• 1208989-37-0 C₃₀H₃₃F₃N₆O₃S 

Relevant academic research and scientific papers

Development and Scope of the Arene-Fused Domino Michael/Mannich Reaction: Application to the Total Syntheses of Aspidosperma Alkaloids (-)-Aspidospermidine, (-)-Tabersonine, and (-)-Vincadifformine

The development and application of the arene-fused domino Michael/Mannich route to the tetrahydrocarbazole (ABE) core of Aspidosperma alkaloids is described. The scope of this novel transformation was studied in terms of the nucleophilic component (i.e., N-sulfinyl metallodienamine) and the electrophilic component (i.e., Michael acceptor). The successful application of this methodology toward the concise total syntheses of classical indole alkaloids (-)-aspidospermidine, (-)-tabersonine, and (-)-vincadifformine in 10-11 steps, respectively, is also discussed.

Studies on diastereofacial selectivity of a chiral tert-butanesulfinimines for the preparation of (S)-3-Methyl-1-(2-piperidin-1-yl-phenyl)butylamine for the synthesis of repaglinide

A new method for the asymmetric synthesis of a series of chiral amines including (S)-3-methyl-1-(2-piperidin-1-yl-phenyl)butylamine (2a) a key intermediate to prepare antidiabetic drug repaglinide by using Ellman's reagent tert-butanesulfinamide. Diastereoselective addition of organometallic reagents to t-butanesulfinimines and followed by acidic and basic treatment. The obtained chiral amines were characterized by NMR, MS and other analytical data.

Unprecedented copper(I) bifluoride complexes: Synthesis, characterization and reactivity

To be or not to bifluoride: Two synthetic pathways to unprecedented N-heterocyclic carbene copper(I) bifluoride complexes have been developed (see scheme). Catalytic tests demonstrated that copper(I) bifluorides are very efficient catalysts, which do not