1209-11-6Relevant academic research and scientific papers
Aniline-Based Inhibitors of Influenza H1N1 Virus Acting on Hemagglutinin-Mediated Fusion
Leiva, Rosana,Barniol-Xicota, Marta,Codony, Sandra,Ginex, Tiziana,Vanderlinden, Evelien,Montes, Marta,Caffrey, Michael,Luque, F. Javier,Naesens, Lieve,Vázquez, Santiago
, p. 98 - 118 (2018/02/10)
Two series of easily accessible anilines were identified as inhibitors of influenza A virus subtype H1N1, and extensive chemical synthesis and analysis of the structure-activity relationship were performed. The compounds were shown to interfere with low pH-induced membrane fusion mediated by the H1 and H5 (group 1) hemagglutinin (HA) subtypes. A combination of virus resistance, HA interaction, and molecular dynamics simulation studies elucidated the binding site of these aniline-based influenza fusion inhibitors, which significantly overlaps with the pocket occupied by some H3 HA-specific inhibitors, indicating the high relevance of this cavity for drug design.
Synthesis and structural chemistry of N-{2-(arylthio/seleno)ethyl} morpholine/piperidine-palladium(II) complexes as potent catalysts for the Heck reaction
Singh, Pradhumn,Das, Dipanwita,Prakash, Om,Singh, Ajai K.
, p. 77 - 84 (2013/02/22)
The reactions of in-situ generated PhS-, PyS- and PhSe- with 4-(2-chloroethyl)morpholine hydrochloride and 1-(2-chloroethyl)piperidine hydrochloride in N2 atmosphere have resulted in N-{2-(arylchalcogeno)ethyl}morpholine/piperidine ligands (L1-L6), which on reaction with Na2PdCl4 at room temperature result in complexes of composition [PdCl2(L)] (1-6; L = L1-L6). All the complexes except 2 have been characterized by X-ray crystallography. The geometry around Pd is nearly square planar in all the cases. The Pd-S and Pd-Se bond lengths are in the ranges 2.2598(10)-2.2795(14) and 2.3541(6)-2.3632(15) ?, respectively. In 77Se{1H} NMR spectra of Pd(II)-complexes with L5 and L6 (Se ligands), the signals appear at higher frequency (up to 187 ppm) with respect to those of corresponding free ligands. Pd(II)-complexes (2, 4 and 6) have been found promising for Heck reaction of aryl bromides with methyl acrylate. The TON values are up to 18 200 and TOF up to 758 h-1 (with complex 6 as catalyst). The Pd-complexes of piperidene derivatives show little higher catalytic efficiency than those of morpholine ones. The positive Hg-test has implied that nano-sized Pd(0) species probably catalyze Heck reactions.
