120964-45-6 Usage
Uses
Different sources of media describe the Uses of 120964-45-6 differently. You can refer to the following data:
1. 3-Deazaneplanocin A is a a powerful inhibitor of S-adenosylhomocysteine hydrolase that has shown potent and selective in vitro and in vivo antiviral activities.
2. 3-Deazaneplanocin A hydrochloride has been used to test its effect on ovarian tumor progression. It has also been used as a S-adenosyl homocysteine hydrolase (SAH) inhibitor in c33A2 cells.
General Description
3-Deazaneplanocin A hydrochloride is a carbocyclic analog of adenosine. It has antimetastatic?property. It is used to treat Ebola virus disease, gastric cancer, myeloma and lymphoma.
Biochem/physiol Actions
3-Deazaneplanocin A (DZNep) is an S-Adenosylhomocysteine Hydrolase inhibitor and histone methyltransferase EZH2 inhibitor. It switches on repressed tumor suppressor genes and induces apoptosis by inhibiting the expression of EZH2.
Check Digit Verification of cas no
The CAS Registry Mumber 120964-45-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,0,9,6 and 4 respectively; the second part has 2 digits, 4 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 120964-45:
(8*1)+(7*2)+(6*0)+(5*9)+(4*6)+(3*4)+(2*4)+(1*5)=116
116 % 10 = 6
So 120964-45-6 is a valid CAS Registry Number.
120964-45-6Relevant articles and documents
Synthesis of 3-Deazaneplanocin A, a Powerful Inhibitor of S-Adenosylhomocysteine Hydrolase with Potent and Selective in Vitro and in Vivo Antiviral Activities
Tseng, Christopher K. H.,Marquez, Victor E.,Fuller, Richard W.,Goldstein, Barry M.,Haines, David R.,et al.
, p. 1442 - 1446 (1989)
The neplanocin A analogue 3-deazaneplanocin A (2b) has been synthesized.A direct SN2 displacement on the cyclopentenyl mesylate 3 by the sodium salt of 6-chloro-3-deazapurine afforded the desired regioisomer 4 as the major product.After deprotection, this material was converted to 3-deazaneplanocin A in two steps.X-ray crystallographic analysis confirmed the assigned structure.Consistent with its potent inhibition of S-adenosylhomocysteine hydrolase, 3-deazaneplanocin A displayed excellent antiviral activity in cell culture against vesicular stomatitis, parainfluenza type 3, yellow fever, and vaccinia viruses.Antiviral activitiy was also displayed in vivo against vaccinia virus by using a mouse tailpox assay.The significantly lower cytotoxicity of 3-deazaneplanocin A, relative to its parent compound neplanocin A, may be due to its lack of conversion to 5'-triphosphate and S-adenosylmethionine metabolites.