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Upstream product

• 50434-36-1 4-nitrophenylacetyl chloride 
• 83-72-7 2-hydroxynaphtho-1,4-quinone 
• 555-16-8 4-nitrobenzaldehdye 
• 100-14-1 4-nitrobenzyl chloride 
• 412323-19-4 2-(4-nitro-benzyl)-4-phenyl-acetoacetic acid ethyl ester 
• 412322-77-1 2-(4-nitro-benzyl)-naphthalene-1,3-diol 

Relevant academic research and scientific papers

A new method to prepare 3-alkyl-2-hydroxy-1,4-naphthoquinones: Synthesis of lapachol and phthiocol

In this article a mild, simple, safe, and chemoselective synthesis and reduction of o-quinone methides to the corresponding 3-alkyl-2-hydroxy-1,4- naphthoquinones, compounds with interesting biological activity, mediated by the formic acid-water system is described. This new one-pot methodology was applied to the synthesis of lapachol and constitutes an efficient and inexpensive alternative for the preparation of this natural bioactive compound Georg Thieme Verlag Stuttgart ? New York.