1209781-79-2Relevant academic research and scientific papers
Microwave assisted synthesis of some 2, 4 dihydroxy 1, 8-naphthyridines and their derivatives devoid of solvent and catalyst
Maringanti, Thirumala Chary,Eppakayala, Laxminarayana,Sripelly, Shiva Shankar,Atmakuri, Narender
experimental part, p. 35 - 41 (2010/03/01)
Reaction of substituted 2-aminopyridines with diethylmalonates yields 2, 4- dihydroxy-l, 8-Naphthyridenes(l-18). The 6-chloro-2, 4-dihydroxy-l, 8- naphthyridene (5) when treated with different reagents varied substituted derivatives are produced. 6- chloro-2, 4-dihydroxy-l, 8-naphthyridene(5) when treated with sodium azide offered 2, 4-dihydroxy-1, 8-naphthyridene-6-thiones (19-21). 6-azido-1, 8-naphthyridine-2, 4- diols(22-24) were obtained by reacting 5 with sodiumazide. The 6-hydrazinyl-l, 8-naphthyridine-2, 4-diols (25-27) and 2, 4, 6-trihydroxy-l, 8-naphthyridenes (28-30) were produced by the reaction of 5 with hydrazine hydrate and acetic acid respectively.
