121003-82-5Relevant academic research and scientific papers
Double Capture of Difluorocarbene by 2-Aminostyrenes Enables the Construction of 3-(2,2-Difluoroethyl)-2-fluoroindoles
Sheng, Heyun,Su, Jianke,Li, Xin,Li, Xue,Song, Qiuling
supporting information, p. 7781 - 7786 (2021/10/25)
We report herein an efficient strategy to construct 3-(2,2-difluoroethyl)-2-fluoroindoles from activated o-aminostyrenes with ethyl bromodi-fluoroacetate as a difluorocarbene source. Through double capture of a difluorocarbene, two different types of fluo
Stereochemical aspects of the "tert-amino effect". Controlled cycloreversion of pyrroloquinoline derivatives and enantioselective introduction of two new optically active centers
Kelderman, E.,Noorlander-Bunt, H. G.,Eerden, J. van,Verboom, W.,Reinhoudt, D. N.
, p. 115 - 123 (2007/10/02)
Conversion of 2-vinyl-N,N-dialkylanilines 2,3(a-o) to pyrroloquinolines 4-13(a-o) occurs via an irreversible suprafacial 1,5 hydrogen shift to a dipolar intermediate which subsequently cyclizes.In refluxing acetonitrile in the presence of zinc chlo
THE TERTIARY AMINO EFFECT IN HETEROCYCLIC SYNTHESIS: MECHANISTIC AND COMPUTATIONAL STUDY OF THE FORMATION OF SIX-MEMBERED RINGS
Groenen, L.C.,Verboom, W.,Nijhuis, W.H.N.,Reinhoudt, D.N.,Van Hummel, G.J.,Feil, D.
, p. 4637 - 4644 (2007/10/02)
The mechanism of the ring closure of -propanedinitrile (2a) to 1,2,3,3a,4,5-hexahydropyrroloquinoline-4,4-dicarbonitrile (3a) has been studied by kinetic measurements using (1)H-NMR spectroscopy.It could be shown
