58028-74-3

Usage

Uses

Used in Pharmaceutical and Agrochemical Industries:
2-Pyrrolidin-1-ylbenzaldehyde is used as an intermediate in the synthesis of various pharmaceuticals and agrochemicals. Its unique chemical structure allows for the development of new compounds with potential therapeutic and pesticidal properties, contributing to the advancement of these industries.
Used in Fragrance Industry:
2-Pyrrolidin-1-ylbenzaldehyde is used as a raw material in the production of perfumes and flavorings. Its sweet, floral odor makes it a valuable component in creating a wide range of fragrances and flavor profiles, enhancing the sensory experience of various consumer products.
Used in Organic Synthesis:
2-Pyrrolidin-1-ylbenzaldehyde has potential applications in the field of organic synthesis, particularly in the development of new chemical compounds for various industrial and research purposes. Its unique structure and reactivity make it a valuable building block for the synthesis of novel compounds with potential applications in various fields, such as materials science, catalysis, and environmental chemistry.

InChI:InChI=1/C11H9NO/c13-9-10-5-1-2-6-11(10)12-7-3-4-8-12/h1-9H

Upstream product

• 73051-88-4 [2-(pyrrolidin-1-yl)phenyl]methanol 
• 123-75-1 pyrrolidine 
• 89-98-5 2-chloro-benzaldehyde 
• 446-52-6 2-Fluorobenzaldehyde 

Downstream Products

• 83716-74-9 1-[((Z)-2-Propenyl)-phenyl]-pyrrolidine 
• 83725-18-2 1-(2-vinylphenyl)pyrrolidine 
• 87698-94-0 Dimethyl <2-(1-Pyrrolidinyl)phenylmethylene>propanedioate 
• 1097259-41-0 diisopropyl 2-(2-(pyrrolidin-1-yl)benzylidene)malonate 
• 1097259-42-1 di-tert-butyl 2-(2-(pyrrolidin-1-yl)benzylidene)malonate 
• 1097259-43-2 dibenzyl 2-(2-(pyrrolidin-1-yl)benzylidene)malonate 
• 1097259-46-5 1,3-diphenyl-2-(2-(pyrrolidin-1-yl)benzylidene)propane-1,3-dione 
• 1097259-45-4 3-(2-(pyrrolidin-1-yl)benzylidene)pentane-2,4-dione 
• 1097259-40-9 diethyl 2-(2-(pyrrolidin-1-yl)benzylidene)malonate 
• 110405-82-8 1-[2-(chloromethyl)phenyl]piperidine hydrochloride 
• 1203-68-5 2-Phenylbenzaldehyde 

Relevant academic research and scientific papers

HPLC-ECD and TDDFT-ECD study of hexahydropyrrolo[1,2-a]quinoline derivatives

Synthesis of racemic hexahydropyrrolo[1,2-a]quinoline derivatives (1-8) was performed by utilizing the Knoevenagel-[1,5]-hydride shift-cyclization domino reaction. Separation of the enantiomers of the chiral products (1-8) was carried out by chiral high-p

Well-controlled ring-opening polymerization of cyclic esters catalyzed by aluminum amido complexes: Kinetics and mechanism

A series of aluminum dimethyl complexes 1-6 bearing N-[2-(pyrrolidinyl)benzyl]anilido ligands were synthesized and well characterized. The molecular structure of complex 1 determined by an X-ray diffraction study indicates the bidentate chelating mode of

Double Capture of Difluorocarbene by 2-Aminostyrenes Enables the Construction of 3-(2,2-Difluoroethyl)-2-fluoroindoles

We report herein an efficient strategy to construct 3-(2,2-difluoroethyl)-2-fluoroindoles from activated o-aminostyrenes with ethyl bromodi-fluoroacetate as a difluorocarbene source. Through double capture of a difluorocarbene, two different types of fluo

Hexafluoroisopropanol-Mediated Redox-Neutral α-C(sp3)-H Functionalization of Cyclic Amines via Hydride Transfer

Hexafluoroisopropanol has been demonstrated as the versatile promoter for redox-neutral α-C(sp3)-H functionalization of cyclic amines via the cascade [1,5]-hydride transfer/cyclization strategy. A wide range of cyclic amines are functionalized

Development of TsDPEN based imine-containing ligands for the copper-catalysed asymmetric Kinugasa reaction

A novel class of chiralN,N,Nimine-containing ligands derived from TsDPEN (N-(p-tosyl)-1,2-diphenylethylene-1,2-diamine) has been developed and applied to the copper-catalyzed asymmetric Kinugasa reaction. The copper(ii) salt proved to be an efficient catalyst precursor, and it provides an efficient way to synthesize enantioenrichedcis-β-lactam. The pathway is air-tolerant and easily manipulated, and the ligands are easy to synthesize. A working model is proposed in which the stereocontrolling step is the [2 + 2] cycloaddition between ketene and imine to explain the observed stereoselectivities.

Catalyst-free photodecarbonylation ofortho-amino benzaldehyde

It is almost a consensus that decarbonylation of the aldehyde group (-CHO) needs to not only be mediated by transition metal catalysts, but also requires severe reaction conditions (high temperature and long reaction time). In this work, inspired by the “conformational-selectivity-based” design strategy, we broke this consensus and discovered a catalyst-free photodecarbonylation of the aldehyde group. It revealed that decarbonylation can be easily achieved with visible light irradiation by introducing a tertiary amine into theortho-position of the aldehyde group. A diverse array of tertiary amines is tolerated by our photodecarbonylation under mild conditions. Furthermore, the (QM) computations of the mechanism and the experiments on well-designed special substrates revealed that our photodecarbonylation depends on the conformational specificity of the aldehyde group and tertiary amine, and occurs through an unusual [1,4]-H shift and a subsequent [1,3]-H shift.

4-(2-(pyrrolidine/piperidine-1-yl)benzyl)-piperazine urea TRPV1 antagonist and preparation method and application thereof

The invention discloses a novel 4-(2-(pyrrolidine/piperidine-1-yl)benzyl)-piperazine urea type TRPV1 antagonist and a preparation method and application thereof. The invention relates to a compound ina general formula (I) and a pharmaceutically acceptable

Redox-Neutral Cascade Dearomatization of Indoles via Hydride Transfer: Divergent Synthesis of Tetrahydroquinoline-Fused Spiroindolenines

The redox-neutral cascade dearomatization of indoles with o-aminobenzaldehydes has been realized via the hydride transfer strategy, achieving the condition- A nd substrate-controlled divergent synthesis of tetrahydroquinoline-fused spiroindolenines. The integration of hydride transfer-involved C(sp3)-H functionalization with dearomatization provides a promising platform for the construction of structurally diverse molecules.

N-Alkylation-Initiated Redox-Neutral [5 + 2] Annulation of 3-Alkylindoles with o-Aminobenzaldehydes: Access to Indole-1,2-Fused 1,4-Benzodiazepines

Described herein is an unprecedented N-Alkylation-initiated redox-neutral [5 + 2] annulation of 3-Alkylindoles with o-Aminobenzaldehydes via a cascade N-Alkylation/dehydration/[1,5]-hydride transfer/Friedel-Crafts alkylation sequence. A series of indole-1,2-fused 1,4-benzodiazepines are facilely constructed in moderate to good yields in one step. This protocol features excellent regioselectivity, metal-free conditions, high step economy, and wide substrate scope.

Spirocyclic Tetramates by Sequential Knoevenagel and [1,5]-Prototropic Shift

Highly functionalized spirocyclic tetramates were prepared via a sequential Knoevenagel reaction and [1,5]-prototropic shift (T-reaction) of bicyclic tetramates. While these compounds isomerize in solution, stable analogues can be prepared via an appropri