1210054-39-9

Basic information

• Product Name: 2-methyl-3-[(4-nitrophenyl)thio]-1H-indole
• Synonyms: 2-methyl-3-[(4-nitrophenyl)thio]-1H-indole
• CAS NO: 1210054-39-9
• Molecular Weight: 284.338
• Mol File: 1210054-39-9.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 2-methyl-3-[(4-nitrophenyl)thio]-1H-indole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-methyl-3-[(4-nitrophenyl)thio]-1H-indole(1210054-39-9)
• EPA Substance Registry System: 2-methyl-3-[(4-nitrophenyl)thio]-1H-indole(1210054-39-9)

Safety Data

• Hazardous Substances Data: 1210054-39-9(Hazardous Substances Data)

Upstream product

• 95-20-5 2-methyl-1H-indole 
• 40208-36-4 N-(p-nitrophenylthio)morpholine 
• 100-32-3 di(p-nitrophenyl) disulfide 

Relevant articles and documents

Electrochemical sulfenylation of indoles with disulfides mediated by potassium iodide

A novel electrochemical system for sulfenylation of indoles with disulfides to generate 3-sulfenylindoles via C-S bond formation mediated by potassium iodide at a low potential was developed. Iodine was electrogenerated from iodide ions at a graphite anode and showed a high catalytic activity for the electrochemical sulfenylation reactions. A variety of aromatic, heteroaromatic and aliphatic disulfides could react with 2-methlyindole to synthesize the corresponding 3-sulfenylindoles in good to excellent yields. In addition, protected and unprotected indoles with various groups, especially electron-donating groups, also performed well in the sulfenylation reactions. The transformation, which proceeded through the redox of iodine and the generation of intermediate 3-iodoindole, provided an efficient and environmentally benign protocol for the synthesis of 3-sulfenylindoles under mild conditions.

A metal-free sulfenylation and bromosulfenylation of indoles: Controllable synthesis of 3-arylthioindoles and 2-bromo-3-arylthioindoles

An efficient metal-free sulfenylation of indoles with disulfides has been developed, leading to 3-arylthioindoles in moderate to excellent yields. Furthermore, bromosulfenylation of indoles with disulfides has been realized for the first time providing a

Iron-catalyzed sulfenylation of indoles with disulfides promoted by a catalytic amount of iodine

Selective sulfenylation of indoles with disulfides using iron(III) fluoride combined with iodine has been developed for the synthesis of sulfenylindoles. In the presence of iron(III) fluoride and iodine, a variety of disulfides underwent the reaction with indoles selectively to afford the corresponding sulfenylindoles in good to excellent yields. Moreover, reactions of indoles with 1,2-diphenyldiselane were also conducted under the same conditions, which smoothly afforded 3-selenylindoles in good yields. Georg Thieme Verlag Stuttgart - New York.