12103-81-0Relevant academic research and scientific papers
Water-Soluble Rhenium Phosphine Complexes Incorporating the Ph2C(X) Motif (X = O-, NH-): Structural and Cytotoxicity Studies
Alshamrani, Abdullah F.,Archibald, Stephen J.,Burke, Benjamin P.,Higham, Lee J.,Prior, Timothy J.,Redshaw, Carl,Roberts, David P.,Stasiuk, Graeme
, p. 2367 - 2378 (2020)
Reaction of [ReOCl3(PPh3)2] or [ReO2I(PPh3)2] with 2,2′-diphenylglycine (dpgH2) in refluxing ethanol afforded the air-stable complex [ReO(dpgH)(dpg)(PPh3)] (1). Treatment of [ReO(OEt)I2(PPh3)2] with 1,2,3-triaza-7-phosphaadamantane (PTA) afforded the complex [ReO(OEt)I2(PTA)2] (2). Reaction of [ReOI2(PTA)3] with dpgH2 led to the isolation of the complex [Re(NCPh2)I2(PTA)3]·0.5EtOH (3·0.5EtOH). A similar reaction but using [ReOX2(PTA)3] (X = Cl, Br) resulted in the analogous halide complexes [Re(NCPh2)Cl2(PTA)3]·2EtOH (4·2EtOH) and [Re(NCPh2)(PTA)3Br2]·1.6EtOH (5·1.6EtOH). Using benzilic acid (2,2′-diphenylglycolic acid, benzH) with 2 afforded the complex [ReO(benz)2(PTA)][PTAH]·EtOH (6·EtOH). The potential for the formation of complexes using radioisotopes with relatively short half-lives suitable for nuclear medicine applications by developing conditions for [Re(NCPh2)(dpg)I(PTA)3] (7)[ReO4]- in a 4 h time scale was investigated. A procedure for the technetium analog of complex [Re(NCPh2)I2(PTA)3] (3) from 99mTc[TcO4]- was then investigated. The molecular structures of 1-7 are reported; complexes 3-7 have been studied using in vitro cell assays (HeLa, HCT116, HT-29, and HEK 293) and were found to have IC50 values in the range of 29-1858 μM.
The trigonal-bipyramidal [ReOI2(PPh3)2] - The first monomeric oxorhenium(IV) complex with monodentate ligands only
Schoultz, Xandri,Gerber, Thomas I.A.,Betz, Richard
, p. 45 - 46 (2016)
The reaction of cis-[ReVO2I(PPh3)2] with 2-(3,5-dimethylpyrazol-1-yl)benzothiazole (dbt) in ethanol led to the isolation of the trigonal-bipyramidal oxorhenium(IV) complex trans-[ReOI2(PPh3
Oxo-Rhenium-Catalyzed Radical Addition of Benzylic Alcohols to Olefins
Bandari, Chandrasekhar,Nicholas, Kenneth M.
, p. 3320 - 3327 (2020/03/23)
Although carbon radicals generated from a variety of alcohol derivatives have proven valuable in coupling and addition reactions, the direct use of alcohols as synthetically useful radical sources is less known. In this report, benzylic alcohols are shown to be effective radical precursors for addition reactions to alkenes when treated with triphenylphosphine or piperidine with the catalyst ReIO2(PPh3)2 (I).
