1210348-01-8Relevant academic research and scientific papers
Bis(4,6-dimethoxy-1,3,5-triazin-2-yl) ether as coupling reagent for peptide synthesis
Jastrzabek, Konrad,Bednarek, Przemyslaw,Kolesinska, Beata,Kaminski, Zbigniew J.
, p. 952 - 961 (2013)
Bis(4,6-dimethoxy-1,3,5-triazin-2-yl) ether (4) was prepared by treatment of 2-hydroxy-4,6-dimethoxy-1,3,5-triazine with 2-chloro-4,6-dimethoxy-1,3,5- triazine in 61% yield. Ether 4, isoelectronic with pyrocarbonates, was found capable to activate carboxylic acids in the presence of 1,4-diazabicyclo[2.2.2] octane (DABCO) to yield, under mild reaction conditions, superactive triazine esters. Versatility of this new coupling reagent was confirmed by condensation of lipophilic and sterically hindered carboxylic acids with amines in 71-98% yield, and by synthesis of peptides, including those containing Aib-Aib sequence, in solution with high yield and high enantiomeric purity. Copyright
Benzotetramisole-catalyzed dynamic kinetic resolution of azlactones
Yang, Xing,Lu, Guojian,Birman, Vladimir B.
scheme or table, p. 892 - 895 (2010/04/29)
(Figure Presented) Enantioselective acyl transfer catalyst benzotetramisole (BTM) has been found to promote dynamic kinetic resolution of azlactones providing di(1-naphthyl)methyl esters of α-amino acids with up to 96% ee.
