121049-91-0Relevant articles and documents
Synthesis of 3,6-diazabicyclo[3.1.1]heptanes as novel ligands for the opioid receptors
Loriga, Giovanni,Manca, Ilaria,Murineddu, Gabriele,Chelucci, Giorgio,Villa, Stefania,Gessi, Stefania,Toma, Lucio,Cignarella, Giorgio,Pinna, Gerard A.
, p. 676 - 691 (2007/10/03)
In an effort to improve diazabicycloalkane-based opioid receptor ligands, N-3(6)-arylpropenyl-N-6(3)-propionyl-3,6-diazabicyclo[3.1.1]heptanes (3A,Ba-i) were synthesized and their affinity and selectivity towards μ-, δ- and κ-receptors were evaluated. The