121097-35-6Relevant academic research and scientific papers
Catalytic asymmetric roskamp reaction of α-Alkyl-α-diazoesters with aromatic aldehydes: Highly enantioselective synthesis of α-Alkyl-β-keto esters
Li, Wei,Wang, Jun,Hu, Xiaolei,Shen, Ke,Wang, Wentao,Chu, Yangyang,Lin, Lili,Liu, Xiaohua,Feng, Xiaoming
supporting information; experimental part, p. 8532 - 8533 (2010/08/06)
The first catalytic enantioselective Roskamp reaction of α-alkyl-α-diazoesters with aromatic aldehydes was realized using a simple chiral N, N′-dioxide-scandium(III) complex. Remarkably, with 0.05 mol % catalyst, the reaction was performed well over a series of substrates, giving the desired products chemoselectively in excellent yields (up to 99%) and enantioselectivities (up to 98% ee) under mild conditions. This protocol provides a promising method for the synthesis of chiral α-alkyl-β- keto esters and 1,3-diols.
Enantioselective aldol chemistry via alkyl enol ethers. Scope of the Lewis acid catalyzed condensation of optically active trimethylsilyl and methyl 2-[(E)-1-alkenyloxy]ethanoates with acetals
Faunce, James A.,Grisso, Bryan A.,Mackenzie, Peter B.
, p. 3418 - 3426 (2007/10/02)
Optically active, mono- and disubstituted trimethylsilyl 2-[(E)-1-alkenyloxy]ethanoates of the type RR1CH = CHOCHR2CO2SiMe3 (R = Me, PhCH2, n-Bu, MeO2CCMe2CH2, PhSCHs
