121125-45-9Relevant articles and documents
Brain-Specific Chemical Delivery Systems for β-Lactam Antibiotics. Synthesis and Properties of Some Dihydropyridine and Dihydroisoquinoline Derivatives of Benzylpenicillin
Pop, Emil,Wu, Whei-Mei,Shek, Efraim,Bodor, Nicholas
, p. 1774 - 1781 (2007/10/02)
Six chemical delivery systems (CDS) were synthesized for benzylpenicillin in order to improve its transport across the blood-brain barrier.The CDS's were based on a dihydropyridine quaternary pyridinium ion redox system, analogous to the naturally occ