1211333-10-6

Basic information

• Product Name: 6-BroMo-2-nitropyridin-3-aMine
• Synonyms: 6-BroMo-2-nitropyridin-3-aMine
• CAS NO: 1211333-10-6
• Molecular Formula: C5H4BrN3O2
• Molecular Weight: 218.00816
• Mol File: 1211333-10-6.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 6-BroMo-2-nitropyridin-3-aMine(CAS DataBase Reference)
• NIST Chemistry Reference: 6-BroMo-2-nitropyridin-3-aMine(1211333-10-6)
• EPA Substance Registry System: 6-BroMo-2-nitropyridin-3-aMine(1211333-10-6)

Safety Data

• Hazardous Substances Data: 1211333-10-6(Hazardous Substances Data)

Usage

General Description

6-Bromo-2-nitropyridin-3-amine is a chemical compound that belongs to the class of organic compounds known as nitropyridines. It has a molecular formula of C5H4BrN3O2. Nitropyridines are compounds containing a pyridine ring which bears a nitro group. This specific compound features a bromide group and an amine, making it functional in various organic reactions. As a chemical intermediary, it often plays a role in the synthesis of more complex organic molecules. At present, information on the practical applications or potential hazards associated with 6-Bromo-2-nitropyridin-3-amine appear limited, indicating that it primarily serves applications in research and development settings, particularly in the field of chemistry.

Upstream product

• 13269-19-7 3-amino-2-nitropyridine 

Downstream Products

• 129012-04-0 2,3-Diamino-6-bromopyridine 

Relevant articles and documents

Synthesis, biological properties and structural study of new halogenated azolo[4,5-b]pyridines as inhibitors of CK2 kinase

The new halogenated 1H-triazolo[4,5-b]pyridines and 1H-imidazo[4,5-b]pyridines were synthesised as analogues of known CK2 inhibitors: 4,5,6,7-tetrabromo-1H-benzotriazole (TBBt) and 4,5,6,7-tetrabromo-1H-benzimidazole (TBBi). Their influence on the activity of recombinant human CK2α, CK2α’ and PIM1 kinases was determined. The most active inhibitors were di- and trihalogenated 1H-triazolo[4,5-b]pyridines (4a, 5a and 10a) with IC50 values 2.56, 3.82 and 3.26 μM respectively for CK2α. Furthermore, effect on viability of cancer cell lines MCF-7 (human breast adenocarcinoma) and CCRF-CEM (T lymphoblast leukemia) of all final compounds was evaluated. Finally, three crystal structures of complexes of CK2α1-335 with inhibitors 4a, 5a and 10a were obtained. In addition, new protocol was used to obtain high-resolution crystal structures of CK2α’Cys336Ser in complex with four inhibitors (4a, 5a, 5b, 10a).

NEW BENZOFURANS SUITABLE AS PRECURSORS TO COMPOUNDS THAT ARE USEFUL FOR IMAGING AMYLOID DEPOSITS

The present invention relates to novel derivatives that are suitable as precursors to compounds that are useful for imaging amyloid deposits in living patients, their compositions, methods of use and processes to make such compounds. The compounds deriving from these precursors are useful in methods of imaging amyloid deposits in brain in vivo to allow antemortem diagnosis of Alzheimer's disease by positron emission tomography (PET) as well as measuring clinical efficacy of Alzheimer's disease therapeutic agents. Furthermore, the present invention also discloses the precursor compounds in crystalline form.