1211407-58-7

Basic information

• Product Name: N-{2-[4-(4-fluorophenyl)piperazin-1-yl]ethyl}-2-quinoxaline carboxamide
• CAS NO: 1211407-58-7
• Molecular Weight: 379.437
• Mol File: 1211407-58-7.mol

Chemical Properties

• CAS DataBase Reference: N-{2-[4-(4-fluorophenyl)piperazin-1-yl]ethyl}-2-quinoxaline carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-{2-[4-(4-fluorophenyl)piperazin-1-yl]ethyl}-2-quinoxaline carboxamide(1211407-58-7)
• EPA Substance Registry System: N-{2-[4-(4-fluorophenyl)piperazin-1-yl]ethyl}-2-quinoxaline carboxamide(1211407-58-7)

Safety Data

• Hazardous Substances Data: 1211407-58-7(Hazardous Substances Data)

Upstream product

• 923569-52-2 2-(2-(4-(4-fluorophenyl)piperazin-1-yl)ethyl)isoindoline-1,3-dione 
• 2252-63-3 1-(4-Fluorophenyl)piperazine 
• 54745-92-5 quinoxaline-2-carboxylic acid chloride 
• 27144-84-9 2-[4-(4-fluoro-phenyl)-piperazin-1-yl]-ethylamine 

Relevant articles and documents

Enhancing a CH-π interaction to increase the affinity for 5-HT 1A receptors

An electrostatic interaction related to a favorable position of the distal phenyl ring and a phenylalanine residue in the binding pocket would explain the higher 5-HT1A affinity of a 4-phenyl-1,2,3,6-tetrahydropyridine (THP) analogue compared t

Chemical modifications on 4-arylpiperazine-ethyl carboxamide derivatives differentially modulate affinity for 5-HT1A, D4.2, and α2A receptors: Synthesis and in vitro radioligand binding studies

A series of substituted 4-aryl-piperazine-ethyl heteroarylcarboxamides were prepared and tested in in vitro radioligand binding studies. The presence of a quinoxaline has a favourable impact in terms of serotonin 5-HT1A versus dopamine D4.2 receptor selectivity. Compounds with a 3-CF3 group at the distal phenyl ring are the most effective in terms of affinity and selectivity for 5-HT1A versus D4.2 receptors. A 4-phenyl-1,2,3,6- tetrahydropyridine in place of the corresponding 4-phenyl-piperazine side chain is also favourable not only for the affinity for 5-HT1A and D4.2 receptors but also in some cases for α2A-adrenoceptors.