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54745-92-5

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54745-92-5 Usage

Chemical Properties

Off-white to tan crystalline powder

Uses

Reactant involved in the synthesis of a variety of inhibitors including:Gelatinase inhibitors for cancer treatmentsmGluR5 non-competitve antagonistsHeterocyclic analogs used as SIRT1 activators3rd Generation multidrug resistance modulatorsReactant involved in preparation of PET ligants for breast cancer resistance protein imaging

General Description

2-Quinoxaloyl chloride reacts with chiral α-hydroxy carboxylic acids to yield UV and fluorescent derivatives.

Check Digit Verification of cas no

The CAS Registry Mumber 54745-92-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,4,7,4 and 5 respectively; the second part has 2 digits, 9 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 54745-92:
(7*5)+(6*4)+(5*7)+(4*4)+(3*5)+(2*9)+(1*2)=145
145 % 10 = 5
So 54745-92-5 is a valid CAS Registry Number.
InChI:InChI=1/C9H5ClN2O/c10-9(13)8-5-11-6-3-1-2-4-7(6)12-8/h1-5H

54745-92-5 Well-known Company Product Price

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  • (Code)Product description
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  • Detail
  • Aldrich

  • (145998)  2-Quinoxaloylchloride  

  • 54745-92-5

  • 145998-250MG

  • 1,140.75CNY

  • Detail
  • Aldrich

  • (145998)  2-Quinoxaloylchloride  

  • 54745-92-5

  • 145998-1G

  • 3,043.17CNY

  • Detail

54745-92-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-Quinoxaloyl chloride

1.2 Other means of identification

Product number -
Other names Quinoxaline-2-carbonyl chloride

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:54745-92-5 SDS

54745-92-5Relevant articles and documents

Design and Discovery of Novel Antifungal Quinoline Derivatives with Acylhydrazide as a Promising Pharmacophore

Yang, Yu-Dong,He, Ying-Hui,Ma, Kun-Yuan,Li, Hu,Zhang, Zhi-Jun,Sun, Yu,Wang, Yu-Ling,Hu, Guan-Fang,Wang, Ren-Xuan,Liu, Ying-Qian

, p. 8347 - 8357 (2021/08/16)

Inspired by natural 2-quinolinecarboxylic acid derivatives, a series of quinoline compounds containing acylhydrazine, acylhydrazone, sulfonylhydrazine, oxadiazole, thiadiazole, or triazole moieties were synthesized and evaluated for their fungicidal activity. Most of these compounds exhibited excellent fungicidal activity in vitro. Significantly, compound 2e displayed the superior in vitro antifungal activity against Sclerotinia sclerotiorum, Rhizoctonia solani, Botrytis cinerea, and Fusarium graminearum with the EC50 values of 0.39, 0.46, 0.19, and 0.18 μg/mL, respectively, and were more potent than those of carbendazim (EC50, 0.68, 0.14, >100, and 0.65 μg/mL, respectively). Moreover, compound 2e could inhibit spore germination of F. graminearum. Preliminary mechanistic studies showed that compound 2e could cause abnormal morphology of cell walls and vacuoles, loss of mitochondrion, increases in membrane permeability, and release of cellular contents. These results indicate that compound 2e displayed superior fungicidal activities and could be a potential fungicidal candidate against plant fungal diseases.

Chemical modifications on 4-arylpiperazine-ethyl carboxamide derivatives differentially modulate affinity for 5-HT1A, D4.2, and α2A receptors: Synthesis and in vitro radioligand binding studies

Graulich, Amaury,Lonard, Marc,Rsimont, Mlissa,Huang, Xi-Ping,Roth, Bryan L.,Ligeois, Jean-Franois

experimental part, p. 56 - 67 (2010/05/18)

A series of substituted 4-aryl-piperazine-ethyl heteroarylcarboxamides were prepared and tested in in vitro radioligand binding studies. The presence of a quinoxaline has a favourable impact in terms of serotonin 5-HT1A versus dopamine D4.2 receptor selectivity. Compounds with a 3-CF3 group at the distal phenyl ring are the most effective in terms of affinity and selectivity for 5-HT1A versus D4.2 receptors. A 4-phenyl-1,2,3,6- tetrahydropyridine in place of the corresponding 4-phenyl-piperazine side chain is also favourable not only for the affinity for 5-HT1A and D4.2 receptors but also in some cases for α2A-adrenoceptors.

Discovery of a potent class I selective ketone histone deacetylase inhibitor with antitumor activity in vivo and optimized pharmacokinetic properties

Kinzel, Olaf,Llauger-Bufi, Laura,Pescatore, Giovanna,Rowley, Michael,Schultz-Fademrecht, Carsten,Monteagudo, Edith,Fonsi, Massimiliano,Paz, Odalys Gonzalez,Fiore, Fabrizio,Steinkühler, Christian,Jones, Philip

supporting information; experimental part, p. 3453 - 3456 (2010/03/05)

The optimization of a potent, class I selective ketone HDAC inhibitor is shown. It possesses optimized pharmacokinetic properties in preclinical species, has a clean off-target profile, and is negative in a microbial mutagenicity (Ames) test. In a mouse xenograft model it shows efficacy comparable to that of vorinostat at a 10-fold reduced dose.

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